Polylactic acid (PLA) is the bioplastic with the highest market share. However, it is mainly produced from first-generation feedstock and there are various inconsistencies in the literature in terms of its production and recycling processes, carbon footprint, and prices. The aim of this study is to compile and contrast these aspects and investigate second-generation PLA production from technical, economic, and ecological perspectives simultaneously. The comprehensive analyses also show the chances and challenges of originating a PLA supply chain in a specific region. Herein, the German Federal State of North Rhine-Westphalia (NRW) has been chosen as a region of interest. In addition to highlighting the industrial capabilities and synergies, the study quantifies and illustrates the locations of different suitable second-generation feedstocks in the region. However, the identified potentials can be challenged by various obstacles such as the high demand of bioresources, feedstock quality, spatial aspects, and logistics. Furthermore, the substantial price gap between PLA and fossil-based plastics can also discourage the investors to include PLA on their portfolios. Thus, the study also provides recommendations to overcome these obstacles and promote the regional value chains of bioplastics which may serve as prototype for other regions.
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http://dx.doi.org/10.1002/gch2.202200218 | DOI Listing |
ACS Omega
December 2024
Faculty V Mechanical Engineering and Transport Systems, Institute of Mechanics, Chair of Stability and Failure of Functionally Optimized Structures, Technische Universität Berlin, Berlin 10623, Germany.
To advance the concept of a circular economy, fungal mycelium-based materials are drawing increased attention as substitutes for nonsustainable materials, such as petroleum-based and animal-derived products, due to their biodegradability, low carbon footprint, and cruelty-free nature. Addressing the challenge of mechanical properties in fungal mycelium products, this study presents a straightforward approach for reinforcing fungal mycelium mats. This is achieved by using two bio-based and biodegradable polymers, poly(3-hydroxybutyrate--3-hydroxyhexanoate) (PHBH) and polylactic acid (PLA), via material extrusion additive manufacturing (MEX AM), commonly known as 3D printing, to produce fungal mycelium-biopolymer composites.
View Article and Find Full Text PDFWe report a method to directly 3-D print complex heterogeneous optical phantoms with programmable tissue-mimicking absorption and scattering properties. The proposed approach utilizes commercially available multi-color mixing extruders and off-the-shelf polylactic acid (PLA) filaments, making this technique low-cost and broadly accessible. We systematically characterized optical properties, including both absorption and reduced scattering coefficients, at a wide range of mixing ratios of gray, white and translucent filaments and validated our hypothesis of a linear-mixing model between the filament mixing ratios and the resulting optical properties.
View Article and Find Full Text PDFTechnol Cancer Res Treat
December 2024
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
Objectives: This study developed a drug delivery system (DDS) using folic acid (FA)-functionalized chitosan (CS) and poly (lactic-co-glycolic acid) (PLGA) nanocarriers for targeted sodium butyrate (NB) delivery to leukemia cells (NALM6). The goal was to enhance NB's therapeutic efficacy while reducing its cytotoxicity to non-malignant cells.
Methods: FA-CS-PLGA nanocarriers were synthesized and characterized using Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), and thermogravimetric analysis (TGA).
J Cosmet Dermatol
December 2024
Magacho Institute for Health Education, Fortaleza, Ceará, Brazil.
Background: A recent study highlighted variability in complication rates among polylactic acid (PLA)-based collagen stimulator fillers, with notably high rate of complications linked to PLLA-Elleva. The study suggested that product-specific characteristics might have greater impact on outcomes than injection techniques.
Methods/results: Through a critical analysis of pertinent literature, this commentary explores how PLLA-Elleva's unique physicochemical properties, particularly its bimodal degradation process, may contribute to the increased nodule formation observed.
J Transl Med
December 2024
Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Background: JAK/STAT3 is one of the critical signaling pathways involved in the occurrence and development of hepatocellular carcinoma (HCC). BBI608 (Napabucasin), as a novel small molecule inhibitor of STAT3, has shown previously excellent anti-HCC effects in vitro and in mouse models. However, low bioavailability, high cytotoxicity and other shortcomings limit its clinical application.
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