AI Article Synopsis
- The study looked at how a medicine called emicizumab helps boys with severe haemophilia A be more active.
- It took place in Egypt and included boys aged 4 to 18 who received the medicine regularly for six months.
- The results showed that after taking emicizumab, the boys' physical activity scores really improved, meaning they were able to do more things!
Article Abstract
Objectives: To assess the effect of emicizumab on physical activity in children with severe haemophilia A.
Methods: The prospective cohortstudy was conducted from October 2021 to April 2022 at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, in collaboration with the Haematology out-patient clinic of the Paediatric Department, Zagazig University, Egypt, and the Paediatric Department of Cairo University Hospital, Egypt, and comprised children aged 4-18 years with severe haemophilia A who received emicizumab prophylaxis. Paediatric Haemophilia Activities List was used to assess physical activity at baseline and aftersix months of regular emicizumab prophylaxis. Data was analysed using SPSS 26.
Results: There were 29 children, all (100%) boys, with mean age 8.7±3.51 years(range 4-15 years. Of them, 17(58.62%) patients were negative for inhibitors. Median Paediatric Haemophilia Activities Listsum score was 59.54 (interquartile range: 50.15-62.05) at baseline which moved up to 84 (interquartile range: 79.05-86.35) post-intervention (p<0.001).
Conclusions: Emicizumab prophylaxis improved the level of physical activity in children with severe haemophilia A.
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| http://dx.doi.org/10.47391/JPMA.EGY-S4-10 | DOI Listing |
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