AI Article Synopsis
- Chromosome segregation during cell division is a highly coordinated process driven by the formation of the mitotic spindle, which is constructed afresh after interphase.
- The γ-tubulin ring complex (γ-TuRC) plays a crucial role as a template for microtubule (MT) nucleation, needed for spindle assembly, but the precise timing and targeting of γ-TuRC to nucleation sites is still being studied.
- Recent research has unveiled new MT nucleation effectors and their functions, offering insights into how various assembly pathways converge to form a functional spindle.
Article Abstract
The cell orchestrates the dance of chromosome segregation with remarkable speed and fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) nucleation, which is dependent on the γ-tubulin ring complex (γ-TuRC), the universal MT template. Although several MT nucleation pathways build the spindle framework, the question of when and how γ-TuRC is targeted to these nucleation sites in the spindle and subsequently activated remains an active area of investigation. Recent advances facilitated the discovery of new MT nucleation effectors and their mechanisms of action. In this review, we illuminate each spindle assembly pathway and subsequently consider how the pathways are merged to build a spindle.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789498 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2023.06.004 | DOI Listing |
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