Most current redox-type nanozyme-based colorimetric sensing platforms are susceptible to interference from the reductant when using chromogenic probe, and the unstable HO used in the peroxidase-like nanozyme-based systems is prone to difficulty in sensing signal reproducibility, while peroxidase-like nanozyme with oxidase-mimicking activity is easy to bring background interference by O. Since the strong structural designability of covalent organic frameworks (COFs) endows them great application value in the sensing fields, therefore, we envision the construction a COF oxidase-like nanozyme-based controllable sensing system that integrates self-reporting, self-correcting and light-responsive functions to avoid these affects. Herein, 3-nitrotyrosine (3-NT) biomarker was selected as model analyte. 1,3,5-triformylphloroglucinol (Tp) and 3,6-diaminoacridine (DA) were acted as building monomers of the multifunctional COF nanozyme (termed as TpDA). Owing to the excellent light-responsive oxidase-mimicking property of TpDA, 3-NT can be efficiently oxidized, the inner filter effect (IFE) between TpDA and the 3-NT oxidation product greatly quenches the intrinsic fluorescence of TpDA, making it a controllable self-reporting system for fluorescence turn-off sensing 3-NT. Additionally, the excessive reactive oxygen species (ROS) that generated continuously during photocatalysis can resist the interference of endogenous reductants. This study not only provides new insights to avoid the interference of HO, background and reductants from conventional redox-type nanozyme-based colorimetric systems but also opens avenues to rational construct versatile COF nanozyme-based sensor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bios.2023.115542 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insights into excitonic behavior in single-atom covalent organic frameworks for efficient photo-Fenton-like pollutant degradation.
Nat Commun
January 2025
Department of Environment, Zhejiang University of Technology, Hangzhou, 310014, China.
The generation of radicals through photo-Fenton-like reactions demonstrates significant potential for remediating emerging organic contaminants (EOCs) in complex aqueous environments. However, the excitonic effect, induced by Coulomb interactions between photoexcited electrons and holes, reduces carrier utilization efficiency in these systems. In this study, we develop Cu single-atom-loaded covalent organic frameworks (Cu/COFs) as models to modulate excitonic effects.
View Article and Find Full Text PDFSingle Na- and K-Ion-Conducting Sulfonated -NH-Linked Covalent Organic Frameworks.
ACS Appl Mater Interfaces
January 2025
Department of Materials Science and Engineering, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.
Highly ion-conductive solid electrolytes of nonlithium ions (sodium or potassium ions) are necessary for pursuing a more cost-effective and sustainable energy storage. Here, two classes of sulfonated -NH-linked covalent organic frameworks (COFs), specifically designed for sodium or potassium ion conduction (named i-COF-2 (Na or K) and i-COF-3 (Na or K)), were synthesized through a straightforward, one-step process using affordable starting materials. Remarkably, these COFs demonstrate high ionic conductivity at room temperature─3.
View Article and Find Full Text PDFCovalent organic frameworks with nitrogen-rich triazine units and suitable pore size for highly efficient adsorption and sensitive detection of bisphenols in water.
J Chromatogr A
January 2025
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address:
Herein, using 1,3,5-triformylphloroglucinol (Tp) and 4,4',4″-(1,3,5-triazine-2,4,6-triyl) tris(1,1'-biphenyl) trianiline (Ttba) as ligands, nitrogen-rich triazine unit-based covalent organic frameworks (COFs) with a suitable pore size, named TpTtba-COFs, were synthesized, and they were employed as adsorbents for the extraction and detection of three bisphenols (BPs)-BP A (BPA), BP B (BPB), and BP S (BPS)-in water. Using 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (Tapt) and 1,3,5-tris(4-aminophenyl)benzene (Tapb) ligands as substitutes for Ttba, nitrogen-rich triazine unit-based COFs with a smaller pore size and nitrogen-poor triazine unit-based COFs, named TpTapt-COFs and TpTapb-COFs, respectively, were also prepared for comparison. The adsorption performances of the three COF adsorbents with regard to the three BPs were tested.
View Article and Find Full Text PDFMetal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants.
J Hazard Mater
January 2025
Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou 350108, China. Electronic address:
Phenolic compounds are a kind of persistent organic pollutants (POPs), which are always a threat to human and environment due to their strong toxicity and low biodegradability. Therefore, developing a reliable method to simultaneously detect phenolic pollutants is of great importance to environmental safety and human health. Herein, we combined the advantages of metal organic frameworks (MOFs) and covalent organic frameworks (COFs) to prepare two cyclic trinuclear unit-based metal covalent organic framework (MCOFs, denoted as Cu-TDH COF and Cu-BDU COF) with large specific surface area, good stability and excellent laccase-like activity.
View Article and Find Full Text PDFExtraction and quantitation of fentanyl in exhaled breath condensate using a magnetic dispersive solid phase based on graphene oxide and covalent organic framework composite and LC-MS/MS analysis.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center of New Material and Green Chemistry, Khazar University, 41 Mehseti Street, Baku AZ1096, Azerbaijan. Electronic address:
Free fentanyl is responsible for its pharmacological effects, but its total concentration is typically determined for therapeutic drug monitoring purposes. Determination of fentanyl concentration can help reduce the prescribed doses, leading to fewer side effects and increased effectiveness. Therefore, predicting free drug concentration in pharmaceutical research is crucial.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!