AI Article Synopsis
- The study investigated the efficacy of a sugarcane-derived cystatin (CaneCPI-5) in reducing erosive dentin wear using two different delivery methods: a solution and a chitosan gel.
- In a crossover design, 15 volunteers tested various solutions, while 16 volunteers tested different gel formulations, both subjected to erosive challenges with citric acid.
- Results showed that CaneCPI-5 significantly reduced dentin loss in both delivery methods, with the chitosan gel combined with CaneCPI-5 offering the best protection against erosion and abrasion.
Article Abstract
Objective: This study evaluated the protective capacity of a sugarcane-derived cystatin (CaneCPI-5) in different vehicles (1-solution and 2-chitosan gel) against erosive dentin wear in situ.
Methods: In part-1, 15 volunteers participated in a crossover protocol (solutions): Water; Elmex™ and CaneCPI-5. The volunteers wore an appliance with 4 dentin samples for 5 days. These samples were treated with a drop of the solutions for 1 min (4X/d), then the acquired pellicle (AP) was formed and the samples were subjected to erosive challenges (EROSION: citric acid, for 90 s, 4X/day). 2X/day, half of the samples were also abraded for 15 s (ABRASION). In part-2, 16 volunteers participated in a crossover protocol (gel): No gel, Chitosan gel, Chitosan gel + NaF and Chitosan gel + CaneCPI-5. The volunteers also wore an appliance. The samples were treated once/day with the gel or not for 4 min, then the AP was formed and the samples were subjected to erosive and abrasive challenges, as reported in part-1. Dentin wear was measured by profilometry. Data were analyzed by two-way RM-ANOVA and Sidak's tests (p < 0.05).
Results: Part-1: Elmex™ and CaneCPI-5 significantly reduced dentin loss in comparison with Water for the EROSION/ABRASION conditions (p < 0.05). Part-2, all the treated groups significantly reduced the dentin loss in comparison to the No gel. The greatest reduction was found for the gel + CaneCPI-5 group for the EROSION/ABRASION (p < 0.05).
Conclusion: The solution and chitosan gel containing CaneCPI-5 protected against erosive dentin wear in situ.
Clinical Relevance: These different vehicles are probably sufficient for protecting people with high risk of developing erosive dentin wear.
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| http://dx.doi.org/10.1007/s00784-023-05175-z | DOI Listing |
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