AI Article Synopsis
- Transcription elongation involves coordination between the transcription machinery and chromatin regulators to produce RNA while maintaining epigenetic features.
- Recent studies show that the histone chaperone Spt6 is crucial for this elongation process and also plays roles in DNA replication and genome integrity.
- The review highlights new findings about Spt6's mechanisms in regulating transcription and its diverse functions in eukaryotic cells.
Article Abstract
Transcription elongation requires elaborate coordination between the transcriptional machinery and chromatin regulatory factors to successfully produce RNA while preserving the epigenetic landscape. Recent structural and genomic studies have highlighted that suppressor of Ty 6 (Spt6), a conserved histone chaperone and transcription elongation factor, sits at the crux of the transcription elongation process. Other recent studies have revealed that Spt6 also promotes DNA replication and genome integrity. Here, we review recent studies of Spt6 that have provided new insights into the mechanisms by which Spt6 controls transcription and have revealed the breadth of Spt6 functions in eukaryotic cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592469 | PMC |
| http://dx.doi.org/10.1016/j.tig.2023.06.008 | DOI Listing |
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