We evaluated impacts of progressive technological updates to bus rapid transit (BRT) systems on in-cabin concentrations of particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5), and the various polyaromatic hydrocarbons (PAHs) to which commuters were exposed. PM2.5 samples were collected and real-time concentrations measured from October 2017 to March 2020 inside cabins of BRT buses equipped with Euro IV, V and VI diesel emission standards in the Mexico City Metropolitan Area (MCMA). For effective comparison, similar samplings and measurements were carried out on trains in the MCMA underground (MCU) system. Peak in-cabin PM2.5 concentrations decreased significantly (p < 0.05) by 35% from Euro IV to Euro V buses, and by 80% from Euro IV to Euro VI buses. PM2.5 concentrations inside Euro VI buses were significantly lower (p < 0.05) than in Euro IV and Euro V buses and in underground trains. The in-cabin excess (ICE) of PM2.5 relative to ambient concentrations was significantly (p < 0.05) higher for Euro IV than for Euro V buses during morning the traffic peak, and consistently higher than for Euro VI buses. Indeed, ICEs calculated for Euro VI buses were always lower than those for electricity-powered underground trains. The frequency of hotspots decreased from Euro IV to Euro VI buses due to the combined effect of low emissions and closed, air-conditioned cabins. Concentrations of total PAHs including carcinogenic species also decreased from Euro IV to Euro V buses and were below limits of detection aboard Euro VI buses. This work shows that in real-life conditions, advanced diesel technologies and cabin design significantly reduce commuters' exposure to PM2.5 and to toxic PAH compounds.
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http://dx.doi.org/10.1016/j.envpol.2023.122236 | DOI Listing |
Sci Adv
January 2025
Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC, Australia.
High-resolution cryo-electron microscopy (cryo-EM) requires costly 200- to 300-keV cryo-transmission electron microscopes (cryo-TEMs) with field emission gun (FEG) sources, stable columns, constant-powered lenses, autoloader, and direct electron detectors (DED). Recent advances in 100-keV imaging with the emergence of sub-200-keV optimized DED technology promises the development of more affordable cryo-TEMs. So far, 100-keV imaging has required microscopes with FEG sources.
View Article and Find Full Text PDFJ Interv Card Electrophysiol
January 2025
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.
Background: Non-response to cardiac resynchronization therapy (CRT) is an important issue in the treatment of heart failure with reduced ejection fraction (HFrEF) and non-left bundle branch block (LBBB). Electrocardiogram-gated myocardial perfusion single-photon emission computed tomography imaging (G-MPI SPECT) is typically used to assess left ventricular (LV) dyssynchrony. This study aimed to determine whether G-MPI parameters are associated with non-responsiveness to CRT.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of California, San Francisco, Weill Institute for Neurosciences, San Francisco, CA, USA.
Background: Alzheimer's disease (AD) and other dementia risk may be influenced by the immune function and associated with several white blood cell type counts. In cognitively normal Black, Hispanic, and non-Hispanic white older adults we related three white blood cell types previously associated with AD risk to tau positron emission tomography (PET) values in the medial temporal lobe (MTL), where tau accumulates early. We assessed whether amyloid positivity moderated this relationship.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA.
Background: Positron emission tomography (PET) tau tracer PI-2620 frequently shows off-target meningeal binding (Figure 1). Of standard regions of interest, only lateral parietal (LP) is contaminated by this. We compare the standardized uptake value ratio (SUVR) in the LP before and after eroding the LP mask to remove meningeal contamination.
View Article and Find Full Text PDFBackground: We recently developed a novel tau-PET summary measure THETA, capturing regional heterogeneity and identifying tau status, using ground truth visual assessments from a large single-center cross-sectional dataset and validated on independent cohorts [1, 2]. In this study, we aimed to evaluate the performance of THETA on longitudinal and histopathology data.
Method: We included longitudinal tau-PET ([F]flortaucipir) data from 696 Mayo Clinic Study of Aging (MCSA) and ADRC participants, with histopathology in n = 90.
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