A new bisabolane-type sesquiterpenoid, named (+)-8-dehydroxylaustrosene (), along with ten known compounds, penicibisabolanes E () and G (), (+)-austrosene (), ()-(+)-11-dehydrosydonic acid (), sydonic acid (), (7,11)-(+)-12-hydroxysydonic acid (), (-)-()-hydroxysydonic acid (), pseudaboydin A (), (-)-(7 ,10)--10-hydroxysydowic acid (), lumichrome (), were identified from the fungus BTBU20213012 isolated from a marine sediment sample from the Western Pacific. The structures of the compounds were identified by HRESIMS and NMR data analysis. Compound showed weak antimicrobial activity against with MIC value of 200 μg/mL.
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http://dx.doi.org/10.1080/14786419.2023.2236764 | DOI Listing |
Fitoterapia
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Five new bisabolane-type sesquiterpenoids (1-5) were isolated from the rhizomes of Curcuma longa, and all of them were oxygen-containing heterocyclic compounds. The structures of the compounds were elucidated using comprehensive spectroscopic techniques, and their absolute configurations were confirmed through electronic circular dichroism (ECD) calculations. All of the compounds were evaluated for their vasorelaxant and anti-inflammatory activities.
View Article and Find Full Text PDFChin J Nat Med
November 2024
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
A phytochemical investigation of the whole plant of Parasenecio rubescens (S. Moore) Y. L.
View Article and Find Full Text PDFFitoterapia
December 2024
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, China; University of Chinese Academy of Sciences, Beijing 100039, China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. Electronic address:
The fruits of Piper longum are called long pepper, which are well-known culinary spice as well as traditional medicine. In present work, thirteen sesquiterpenes including four undescribed compounds were isolated from P. longum fruits.
View Article and Find Full Text PDFNat Prod Res
June 2024
Department of Emergency Medicine, Yizheng People's Hospital, Yangzhou, China.
Endophytic fungi can produce attractive secondary metabolites with various biological activities that have contributed significantly to pharmacotherapy. In this study, three bisabolane-type sesquiterpenoids, including a new one, namely, inonotic acid C (), together with previously reported compounds ()-(+)-11-dehydrosydonic acid () and sydonic acid (), were isolated from a marine algal-derived endophytic fungus MZY-202312-521. Their structures were determined by means of extensive spectroscopic analyses.
View Article and Find Full Text PDFMolecules
April 2024
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
The fungus sp. Z184, harvested from the leaves of (L.) Á.
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