Intracranial Rosai-Dorfman disease: A case report.

Asian J Surg

Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China; Tianjin Neurosurgical Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Electronic address:

Published: November 2023

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http://dx.doi.org/10.1016/j.asjsur.2023.07.046DOI Listing

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To report a rare case of Rosai-Dorfman-Destombes (RDD) disease in a teenage girl exhibiting mild fever, night chills, vertigo, and progressive bilateral vision and hearing loss. Case report of a 15-year-old girl who underwent extensive ophthalmic multimodal imaging and a comprehensive workup evaluation. Multiple choroid lesion masses in both eyes associated with systemic multifocal lymphadenopathy, involvement of the paranasal sinuses, and unusual intracranial manifestations well-shown by magnetic resonance imaging (MRI) and whole-body PET-scan.

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Article Synopsis
  • Rosai-Dorfman disease (RDD) is a rare histiocytosis often presenting with systemic symptoms, but this case highlights its unusual progression to the brain after skull base involvement.
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  • The study emphasizes the need for timely surgical treatment to prevent local and systemic disease progression, despite RDD typically being regarded as benign.
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Objective: Rosai-Dorfman disease (RDD) is a rare benign proliferative disorder of histiocytes. The study discusses the intracranial RDD approach, its management, and its outcome.

Methods: It is a retrospective study performed in a tertiary center, the National Institute of Mental Health and Neuroscience, Bangalore, from January 2010 to December 2022.

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