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Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats. | LitMetric

Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats.

Microbes Infect

Immunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic", National Institute of the Republic of Serbia, University of Belgrade, 142 Bulevar Despota Stefana, 11000, Belgrade, Serbia. Electronic address:

Published: December 2023

AI Article Synopsis

Article Abstract

Since the realization that the lungs are not sterile but are normally inhabited by various bacterial species, studies have been conducted to define healthy lung microbiota and to investigate whether it changes during lung diseases, infections, and inflammation. Using next-generation sequencing, we investigated bacterial microbiota from whole lungs in two rat strains (previously shown to differ in gut microbiota composition) in a healthy state and during pulmonary infection caused by the opportunistic fungus Aspergillus fumigatus. No differences in alpha diversity indices and microbial composition between DA and AO rats before infection were noted. Fungal infection caused dysbiosis in both rat strains, characterized by increased alpha diversity indices and unchanged beta diversity. The relative abundance of genera and species was increased in DA but decreased in AO rats during infection. Changes in lung microbiota coincided with inflammation (in both rat strains) and oxidative stress (in DA rats). Disparate response of lung microbiota in DA and AO rats to pulmonary fungal infection might render these two rat strains differentially susceptible to a subsequent inflammatory insult.

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Source
http://dx.doi.org/10.1016/j.micinf.2023.105186DOI Listing

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