Genomic analysis of the MLST population structure and antimicrobial resistance genes associated with in Mexico.

Genome

Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Santiago de Querétaro C.P. 76010, Querétaro, Mexico.

Published: December 2023

AI Article Synopsis

  • The study investigates the population structure and antimicrobial resistance (AMR) genes in a common foodborne pathogen found in Mexico, analyzing 2,561 strains.
  • Key sources of these strains include food (44.28%), the environment (27.41%), animals (24.83%), and humans (3.48%), highlighting the importance of food safety.
  • The research identifies prevalent serovars, frequent sequence types, and 78 AMR genes across various classes, offering critical data for public health strategies to combat foodborne diseases and enhance genomic monitoring.

Article Abstract

is one of the most commonly reported foodborne pathogens by public health agencies worldwide. In this study, the multilocus sequence typing (MLST) population structure and frequency of antimicrobial resistance (AMR) genes were evaluated in strains from Mexico ( = 2561). The most common sources of isolation were food (44.28%), environment (27.41%), animal-related (24.83%), and human (3.48%). The most prevalent serovars were Newport (8.51%), Oranienburg (7.03%), Anatum (5.78%), Typhimurium (5.12%), and Infantis (4.57%). As determined by the 7-gene MLST scheme, the most frequent sequence types were ST23, ST64, and ST32. The core genome MLST scheme identified 132 HC2000 and 195 HC900 hierarchical clusters, with the HC2000_2 cluster being the most prevalent in Mexico ( = 256). A total of 78 different AMR genes belonging to 13 antimicrobial classes were detected in 638 genomic assemblies of . The most frequent class was aminoglycosides (31.76%), followed by tetracyclines (12.53%) and sulfonamides (11.91%). These results can help public health agencies in Mexico prioritize their efforts and resources to increase the genomic sequencing of circulating strains. Additionally, they provide valuable information for local and global public health efforts to reduce the impact of foodborne diseases and AMR.

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Source
http://dx.doi.org/10.1139/gen-2023-0007DOI Listing

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