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| http://dx.doi.org/10.18632/oncotarget.28478 | DOI Listing |
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Addendum: Systemic AL amyloidosis: current approach and future direction.
Oncotarget
July 2023
Department of Hematology-Oncology, Myeloma and Amyloidosis Program, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL 33331, USA.
Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study.
Rheumatology (Oxford)
June 2023
Service de Dermatologie et Allergologie, Sorbonne Université, Faculté de Médecine, AP-HP, Hôpital Tenon, Paris, France.
Objectives: To describe the clinical and pathological features of biopsy-proven cutaneous vasculitis (CV) associated with SLE, focusing on diagnosis classification and impact on overall SLE activity.
Methods: Retrospective multicentric cohort study including SLE patients with biopsy-proven CV identified by (i) data from pathology departments of three university hospitals and (ii) a national call for cases. SLE was defined according to 1997 revised ACR and/or 2019 ACR/EULAR criteria.
The Impact of COVID-19 on Older Adults' Perceptions of Virtual Care: Qualitative Study.
JMIR Aging
October 2022
School of Public Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Background: In response to the COVID-19 pandemic, older adults worldwide have increasingly received health care virtually, and health care organizations and professional bodies have indicated that virtual care is "here to stay." As older adults are the highest users of the health care system, virtual care implementation can have a significant impact on them and may pose a need for additional support.
Objective: This research aims to understand older adults' perspectives and experiences of virtual care during the pandemic.
Amyotrophic lateral sclerosis and intestinal microbiota-toward establishing cause and effect.
Gut Microbes
November 2020
Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
The intestinal microbiota may be involved, through metabolic gut-brain interactions, in a variety of neurological conditions. In this addendum, we summarize the findings of our recent study investigating the potentially modulatory influence of the microbiome in a transgenic ALS mouse model, and the possible application to human disease. We found that transgenic mice show evidence of dysbiosis, even at the pre-symptomatic stage, and have a more severe disease course under germ-free conditions or after receiving broad-spectrum antibiotics.
View Article and Find Full Text PDFInsights from pharmacokinetic models of host-microbiome drug metabolism.
Gut Microbes
May 2020
Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT, USA.
Increasing evidence suggests a role of the gut microbiota in patients' response to medicinal drugs. In our recent study, we combined genomics of human gut commensals and gnotobiotic animal experiments to quantify microbiota and host contributions to drug metabolism. Informed by experimental data, we built a physiology-based pharmacokinetic model of drug metabolism that includes intestinal compartments with microbiome drug-metabolizing activity.
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