AI Article Synopsis
- The study aimed to evaluate the effectiveness and safety of pamiparib combined with tislelizumab in patients with advanced solid tumors who had already received treatment.
- A total of 180 patients were analyzed, revealing an overall objective response rate (ORR) of 20.0%, with the highest response seen in patients with triple-negative breast cancer (ORR: 47.4%).
- While the combination treatment showed some antitumour activity, it also resulted in high rates of severe side effects, with 61.7% of patients experiencing grade 3 or higher adverse events.
Article Abstract
Background: The aim of this study was to investigate the antitumour activity, safety, and tolerability of pamiparib plus tislelizumab in patients with previously treated advanced solid tumours.
Methods: In this study, patients were enrolled into eight arms by tumour type. All received pamiparib 40 mg orally twice daily plus tislelizumab 200 mg intravenously every 3 weeks. The primary endpoint was objective response rate (ORR), assessed by the investigator per Response Evaluation Criteria in Solid Tumours v1.1. Secondary endpoints included duration of response (DoR), safety, and tolerability.
Results: Overall, 180 patients were enrolled. In the overall population, the ORR was 20.0% (range: 0-47.4 across study arms), with median DoR of 17.1 months (95% confidence interval [CI]: 6.2, not estimable [NE]). The highest ORR was observed in the triple-negative breast cancer (TNBC) arm (patients with BRCA1/2 mutations and/or homologous recombination deficiency) (ORR: 47.4%; median DoR: 17.1 months [95% CI: 3.0, NE]). Treatment-emergent adverse events (TEAEs) of ≥Grade 3 occurred in 61.7% of patients. Serious TEAEs occurred in 50.0% of patients.
Conclusions: Pamiparib plus tislelizumab showed a variable level of antitumour activity in patients with advanced solid tumours, with the highest ORR in TNBC and was associated with a manageable safety profile.
Clinical Trial Registration: ClinicalTrial.gov: NCT02660034.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449784 | PMC |
| http://dx.doi.org/10.1038/s41416-023-02349-0 | DOI Listing |
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