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The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma. | LitMetric

AI Article Synopsis

  • * Analysis through panel sequencing reveals strong similarity in genetic profiles between initial diagnosis and cancer relapse, with minimal discrepancies observed.
  • * Findings suggest that the cancer's genome remains stable during relapse, indicating that resistance to chemotherapy doesn’t typically arise from common genetic alterations.

Article Abstract

The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a cohort of 276 women with relapsed ovarian high grade serous carcinoma in the BriTROC-1 study. Panel sequencing shows close concordance between diagnosis and relapse, with only four discordant cases. There is also very strong concordance in copy number between diagnosis and relapse, with no significant difference in purity, ploidy or focal somatic copy number alterations, even when stratified by platinum sensitivity or prior chemotherapy lines. Copy number signatures are strongly correlated with immune cell infiltration, whilst diagnosis samples from patients with primary platinum resistance have increased rates of CCNE1 and KRAS amplification and copy number signature 1 exposure. Our data show that the ovarian high grade serous carcinoma genome is remarkably stable between diagnosis and relapse and acquired chemotherapy resistance does not select for common copy number drivers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359414PMC
http://dx.doi.org/10.1038/s41467-023-39867-7DOI Listing

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