AI Article Synopsis
- Pulmonary exacerbations treated with oral antibiotics significantly impact lung function decline in cystic fibrosis patients, but the exact factors influencing lung function response to these treatments are not well understood.
- A retrospective cohort study analyzed data from pediatric and adult cystic fibrosis patients in Toronto, measuring changes in lung function (FEV) from the start to the end of antibiotic treatment.
- Results showed that a larger decrease in lung function from baseline to the start of treatment correlated with greater improvements during treatment, and that older females experienced less benefit compared to younger males.
Article Abstract
Pulmonary exacerbations treated with oral antibiotics (oPEx) have a significant effect on lung function decline in people with cystic fibrosis (CF). However, factors associated with lung function response with oPExs are not well defined. We performed a retrospective cohort study of pediatric and adult patients with CF followed in the Toronto CF Database. Lung function response was measured both as the change in forced expiratory volume in 1 second (FEV) from Day 0 of antibiotic therapy to end of treatment as well as from baseline to end of treatment. Drop from baseline to Day 0 FEV was strongly associated with lung function response (p<0.001). Greater FEV improvements were associated with longer antibiotic treatment durations. Older, female patients had less improvements in FEV at end of treatment compared to younger, male patients.
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| http://dx.doi.org/10.1016/j.jcf.2023.06.015 | DOI Listing |
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