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Cerebro-spinal flow pattern in the cervical subarachnoid space of healthy volunteers: Influence of the spinal cord morphology.
PLoS One
August 2024
Laboratoire de Biomécanique Appliquée, UMRT24, Aix Marseille Université, Marseille, France.
Introduction: Toward further cerebro-spinal flow quantification in clinical practice, this study aims at assessing the variations in the cerebro spinal fluid flow pattern associated with change in the morphology of the subarachnoid space of the cervical canal of healthy humans by developing a computational fluid dynamics model.
Methods: 3D T2-space MRI sequence images of the cervical spine were used to segment 11 cervical subarachnoid space. Model validation (time-step, mesh size, size and number of boundary layers, influences of parted inflow and inflow continuous velocity) was performed a 40-year-old patient-specific model.
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus.
Fluids Barriers CNS
August 2024
Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris, 22 rue Méchain, F-75014, France.
Article Synopsis
- Group B Streptococcus (GBS), particularly the hypervirulent CC17 clone, is a major cause of neonatal meningitis linked to significant mortality and disability.
- This study examined how GBS CC17 interacts with the choroid plexus, a critical part of the blood-cerebrospinal fluid barrier, using both mouse models and in vitro cell studies.
- Results showed that GBS CC17 effectively invades choroid plexus cells through a specific mechanism, leading to immune responses and potential pathways for brain infections.
: a rare cause of rhomboencephalitis in an immunocompetent patient.
Br J Hosp Med (Lond)
May 2024
Department of Anaesthetics and Critical Care Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
We present an unusual case of rhomboencephalitis in a young, healthy patient. Although meningitis is usually associated with immunodeficiency, rhomboencephalitis is more commonly seen in immunocompetent patients. The wide differential for rhomboencephalitis can create a diagnostic challenge.
View Article and Find Full Text PDFA case report of diagnosis and dynamic monitoring of meningitis with NGS.
Open Life Sci
November 2023
Department of Emergency Medicine, Shanghai Jiaotong University Affiliated Sixth People' Hospital, No. 600 Yishan Road, Xuhui District, Shanghai 200233, China.
() infections of the central nervous system are deadly and have vague symptoms. Traditional cerebro spinal fluid culture has a low positive rate, and because antibiotic use is common following therapy, it is more challenging to assess the response from pathogen content. In this case, a 66-year-old man who had a fever, a headache, and vomit was admitted to the hospital.
View Article and Find Full Text PDFSurgical Treatment of Spheno-Orbital Meningiomas: A Systematic Review and Meta-Analysis of Surgical Techniques and Outcomes.
J Clin Med
September 2023
Division of Neurosurgery, Department of Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy.
Background: Spheno-orbital meningiomas (SOMs) are rare tumors arising from the meninges surrounding the sphenoid bone and orbital structures. Surgical resection is the primary treatment approach for SOMs. Several surgical approaches have been described during the decades, including microsurgical transcranial (MTAs), endoscopic endonasal (EEAs), endoscopic transorbital (ETOAs), and combined approaches, and the choice of surgical approach remains a topic of debate.
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