The ever-growing aging population has led to an increasing need for removable partial dentures (RPDs) since they are typically the least expensive treatment options for partial edentulism. However, the digital design of RPDs remains challenging for dental technicians due to the variety of partially edentulous scenarios and complex combinations of denture components. To accelerate the design of RPDs, we propose a U-shape network incorporated with Transformer blocks to automatically generate RPD clasps, one of the most frequently used RPD components. Unlike existing dental restoration design algorithms, we introduce the voxel-based truncated signed distance field (TSDF) as an intermediate representation, which reduces the sensitivity of the network to resolution and contributes to more smooth reconstruction. Besides, a selective insertion scheme is proposed for solving the memory issue caused by Transformer blocks and enables the algorithm to work well in scenarios with insufficient data. We further design two weighted loss functions to filter out the noisy signals generated from the zero-gradient areas in TSDF. Ablation and comparison studies demonstrate that our algorithm outperforms state-of-the-art reconstruction methods by a large margin and can serve as an intelligent auxiliary in denture design.
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http://dx.doi.org/10.1109/JBHI.2023.3295387 | DOI Listing |
PLoS One
January 2025
School of Mathematics and Statistics, Nanjing University of Information Science and Technology, Nanjing, Jiangsu, China.
Optical Coherence Tomography (OCT) offers high-resolution images of the eye's fundus. This enables thorough analysis of retinal health by doctors, providing a solid basis for diagnosis and treatment. With the development of deep learning, deep learning-based methods are becoming more popular for fundus OCT image segmentation.
View Article and Find Full Text PDFBMC Cancer
December 2024
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.
Background: Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Early detection of precursor lesions or early-stage cancer could hamper cancer development or improve survival rates. Liquid biopsy, which detects tumor biomarkers, such as mutations, in blood, is a promising avenue for cancer screening.
View Article and Find Full Text PDFEur J Hum Genet
November 2024
Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
De novo synthesis of purines (DNPS) is a biochemical pathway that provides the purine bases for synthesis of essential biomolecules such as nucleic acids, energy transfer molecules, signaling molecules and various cofactors. Inborn errors of DNPS enzymes present with a wide spectrum of neurodevelopmental and neuromuscular abnormalities and accumulation of characteristic metabolic intermediates of the DNPS in body fluids and tissues. In this study, we present the second case of PAICS deficiency due to bi-allelic variants of PAICS gene encoding for a missense p.
View Article and Find Full Text PDFSensors (Basel)
November 2024
School of Computer Science and Technology, North University of China, Taiyuan 030051, China.
Simultaneous Localization And Mapping (SLAM) algorithms play a critical role in autonomous exploration tasks requiring mobile robots to autonomously explore and gather information in unknown or hazardous environments where human access may be difficult or dangerous. However, due to the resource-constrained nature of mobile robots, they are hindered from performing long-term and large-scale tasks. In this paper, we propose an efficient multi-robot dense SLAM system that utilizes a centralized structure to alleviate the computational and memory burdens on the agents (i.
View Article and Find Full Text PDFJ Clin Immunol
November 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Università degli Studi di Genova, Genova, Italy.
Multisystem inflammatory syndrome in children (MIS-C) has been reported in patients with inborn errors of immunity (IEI), providing insights into disease pathogenesis. Here, we present the first case of MIS-C in a child affected by Wiskott-Aldrich syndrome (WAS) gene mutation, elucidating underlying predisposing factors and the involved inflammatory pathways. Genetic analysis revealed a frameshift truncating variant in the WAS gene, resulting in WAS protein expression between mild and severe forms, despite a clinical phenotype resembling X-linked thrombocytopenia (XLT).
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