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http://dx.doi.org/10.1007/s13246-023-01301-z | DOI Listing |
Brief Bioinform
November 2024
Center for Genomics and Biotechnology, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, No. 15 Shangxiadian Road, Cangshan District, Fuzhou 350002, China.
Spatial transcriptomics (ST) technologies enable dissecting the tissue architecture in spatial context. To perceive the global contextual information of gene expression patterns in tissue, the spatial dependence of cells must be fully considered by integrating both local and non-local features by means of spatial-context-aware. However, the current ST integration algorithm ignores for ST dropouts, which impedes the spatial-aware of ST features, resulting in challenges in the accuracy and robustness of microenvironmental heterogeneity detecting, spatial domain clustering, and batch-effects correction.
View Article and Find Full Text PDFUnlabelled: Cytoplasmic proteins must recruit to membranes to function in processes such as endocytosis and cell division. Many of these proteins recognize not only the chemical structure of the membrane lipids, but the curvature of the surface, binding more strongly to more highly curved surfaces, or 'curvature sensing'. Curvature sensing by amphipathic helices is known to vary with membrane bending rigidity, but changes to lipid composition can simultaneously alter membrane thickness, spontaneous curvature, and leaflet symmetry, thus far preventing a systematic characterization of lipid composition on such curvature sensing through either experiment or simulation.
View Article and Find Full Text PDFActa Otorhinolaryngol Ital
December 2024
Orthodontics and Pediatric Dentistry Unit, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Osteochondroma (OC) is a common bone tumour that rarely affects the mandibular condylar process. This pathology can show typical clinical features, such as facial asymmetry, deviation of the chin and dental inferior midline, changes in condylar morphology and malocclusion with an increased posterior mandibular vertical height. The management of condylar OC is a debated topic among surgeons.
View Article and Find Full Text PDFAm J Ind Med
January 2025
EHS Department, M&M SBG, L&T Construction (Larsen &Toubro), Kolkata, West Bengal, India.
Background: Globally, construction jobs are associated with serious occupational safety and health (OSH) risks. In large construction projects, managing OSH risks is challenging due to a multitude of factors, and it is important to have sound management strategies and innovative solutions to tackle these ever-evolving OSH risks. Safety surveillance plays a pivotal role in accident prevention in the construction industry.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Epidemiology, School of Health, Mashhad University of Medical Science, Mashhad, Iran.
Background: In order to increase the stability of tibial component in total knee arthroplasty (TKA), intramedullary stem extensions (SE) have been developed. The aim of this systematic review and meta-analysis is to address the critical knowledge gap on post-operative outcomes and complications rate comparison between tibial component with SE compared to the tibial component standard configuration (SC) in primary cemented TKA.
Methods: We conducted a comprehensive search of online databases, including Pubmed, Embase, ISI Web of science, Cochrane Library, and Scopus, using the following MeSH terms, (total knee arthroplasty) OR (TKA) OR (total knee replacement) AND (Tibial stem) OR (stem extension) OR (long stem).
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