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Hypomelanosis of Ito (HI), a neurocutaneous syndrome, is characterized by skin depigmentation and skeletal, muscular, central nervous system, cardiac, and renal manifestations. A wide variety of cutaneous manifestations besides depigmentation have been reported. Herein we describe a 23-year-old woman with HI whose extracutaneous symptoms included severe mental and motor impairment, convulsions, and deformity of the orofacial region.
View Article and Find Full Text PDFChanges in Gene Expression Related to Atopic Dermatitis in Mothers and Infants Following VOC Exposure.
Int J Mol Sci
November 2024
Department of Medicinal and Life Sciences, Hanyang University, Sangnok-gu, Ansan 15588, Gyeonggi-do, Republic of Korea.
Environmental pollutants, particularly volatile organic compounds (VOCs), are associated with various diseases, including atopic dermatitis (AD). However, despite numerous studies on AD, there is a lack of research on the impact of various environmental exposures on mothers and infants. This study, therefore, investigated the effects of maternal exposure to specific VOCs (toluene, xylene, and benzene) on the expression of AD-related genes in mothers and their infants.
View Article and Find Full Text PDFClinical perspectives on post-induction maintenance therapy in patients with acute myeloid leukaemia in remission who are ineligible for allogeneic haematopoietic stem cell transplantation.
Br J Haematol
January 2025
Université Cote d'Azur, CHU de Nice, Service d'hématologie, Nice, France.
For patients with acute myeloid leukaemia (AML) who achieve complete remission (CR) after induction therapy, subsequent allogeneic haematopoietic stem cell transplantation (allo-HSCT) reduces the risk of relapse. However, not all patients are eligible, warranting effective alternative maintenance strategies. Oral azacitidine is the only non-targeted therapy approved by both the United States (US) Food and Drug Administration and the European Medicines Agency for the maintenance or continued treatment of allo-HSCT-ineligible patients with AML achieving CR or CR with incomplete haematological recovery following induction chemotherapy.
View Article and Find Full Text PDFIgG-Binding Peptidomimetic Mixed-Charge Polymer-Modified Resins for Chromatographic Purification of Antibodies.
ACS Appl Mater Interfaces
December 2024
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Article Synopsis
- The study introduces a new method for antibody purification using a pH-responsive mixed-charge polymer that mimics IgG-binding peptides, overcoming issues like high costs and loss of antibody activity.
- The method utilizes the protein A mimetic resin (HisMA20-EEMA) to retain and elute antibodies such as rituximab effectively, achieving 90% recovery across 100 consecutive purifications.
- This novel approach demonstrates advantages in durability, cost-effectiveness, and mild elution conditions, highlighting its potential for improving current antibody purification techniques.
Rapid, Sensitive, and Specific Microbial Whole-Cell Biosensor for the Detection of Histamine: A Potential Food Toxin.
J Agric Food Chem
December 2024
Chemical Biology Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India.
Histamine is a biogenic amine; its level indicates food quality, as elevated levels cause food poisoning. Therefore, monitoring food at each step during processing until it reaches the consumer is crucial, but current techniques are complicated and time-consuming. Here, we designed a whole-cell biosensor using a histamine-responsive genetic element expressing a fluorescent protein in the presence of the cognate target.
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