AI Article Synopsis
- NUT midline carcinoma (NMC) is a rare and aggressive tumor primarily affecting young adults and children, especially in midline areas.
- Primary pulmonary NMC is particularly poorly understood in the literature and requires specific management due to its high fatality rate.
- Recent clinical trials have shown promising results for targeted therapies like BET inhibitors and histone deacetylase inhibitors, as illustrated by a case report of a young male with NMC and widespread bony metastasis.
Article Abstract
Nuclear protein in testis (NUT) midline carcinoma is a poorly differentiated tumor, is more common in midline anatomic sites, and involves young adults and children mainly. Primary pulmonary NUT midline carcinoma (NMC) is a rare and poorly defined entity in the prevailing literature. Being a highly aggressive and fatal neoplasm, it gets incumbent for the oncologists and the pathologists to be aware of this entity as it holds distinct management protocol and prognosis. Currently, BET inhibitors (BETi) and histone deactylase inhibitors have shown promising results as targeted therapies in clinical trials in head and neck NMC. We present a case report of NMC of primary pulmonary location in a young male with widespread bony metastasis.
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| http://dx.doi.org/10.4103/jcrt.jcrt_1887_20 | DOI Listing |
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