Objective: (1) To determine whether Oxley's modified cranial closing wedge osteotomy (CCWO) results in a tibial plateau angle (TPA) of 5° in silico, (2) compare in silico to clinical postoperative TPA and (3) determine the impact of ostectomy distalization in silico.
Study Design: Cross-sectional retrospective radiographic in silico study.
Sample Population: A total of 100 stifle radiographs; 90 dogs (small ≤25 kg = 84; large >25 kg = 16).
Methods: Tibial plateau angles were measured preoperatively (TPA ), after in silico planning (TPA ), and postoperatively (TPA ). Virtual ostectomies were evaluated for plate fit. Postoperative ostectomy position was measured. Virtual ostectomies were performed 5/7.5/10/15 mm from the patellar tendon insertion in 10 dogs from each preoperative TPA category (≤20°/21-25°/ 26-30°/31-35°/>35°). Comparisons for TPA , TPA , and TPA were made between small and large dogs, and the outcome to the target 5° between TPA categories and ostectomy positions.
Results: Mean ± SD TPA was 28.6 ± 6.2° and higher in small than large dogs. Mean TPA was 7.6 ± 2.7°. Plate fit was appropriate in all. In silico, TPAs were greater than 5° except for cases with TPA > 35°. Median TPA was 5.5° (-4-21) and was higher in small (7°) than large (4.5°) dogs. Postoperative ostectomy position was more distal than Oxley's guidelines. When distalized >7.5 mm in silico, the magnitude of under-correction increased.
Conclusions: Oxley's modified CCWO did not result in TPA of 5° in most cases. Ostectomy distalization exacerbated under-correction.
Clinical Impact: Current guidelines should be modified to achieve 5° TPA postoperatively.
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http://dx.doi.org/10.1111/vsu.13998 | DOI Listing |
Anal Chem
December 2024
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
The surge of lateral flow immunoassays (LFAs) stimulates researchers to explore the novel vibrant aggregation-induced emission luminogen (AIEgen)-doped nanoparticles to improve the accuracy and reliability of LFAs. However, the loading amount of AIEgens currently used for the LFA in microspheres is limited due to their symmetrical large conjugated skeleton structure, which significantly reduces the fluorescence brightness of the signal reporter in the LFA. Herein, an ionic AIEgens with a donor-acceptor type was developed as the signal reporter of the LFA for C-reactive protein (CRP).
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View Article and Find Full Text PDFPLoS Pathog
December 2024
Department of Medicine, UConn Health, Farmington, Connecticut, United States of America.
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View Article and Find Full Text PDFEur Spine J
December 2024
Department of Orthopaedic Surgery, Columbia University Irving Medical Center, The Och Spine Hospital at NewYork Presbyterian, New York, NY, 10032, USA.
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J Ethnopharmacol
December 2024
Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:
Ethnopharmacological Relevance: Delayed tissue-type plasminogen activator (t-PA) thrombolysis, which has a restrictive therapeutic time window within 4.5 h following ischemic stroke (IS), increases the risk of hemorrhagic transformation (HT) and subsequent neurotoxicity. Studies have shown that the NLRP3 inflammasome activation reversely regulated by the PGC-1α leads to microglial polarization and pyroptosis to cause damage to nerve cells and the blood-brain barrier.
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