Introduction: Pseudoangiomatous stromal hyperplasia (PASH) presenting as gigantomastia is rare in pregnancy but can result in severe clinical consequences for both mother and fetus. . A 43-year-old female with a history of biopsy-proven bilateral PASH presented at 22 3/7 weeks gestation with massive bilateral breast enlargement that was symptomatic. After multidisciplinary care, she underwent bilateral mastectomies and delivered at term with no additional complications.
Conclusion: Pregnant women who undergo mastectomies for PASH-induced gigantomastia during their second trimesters will likely recover quickly, and fetal risks are low. Given the rarity of this breast entity, management guidelines are sparse. Our case report is an effort to comprehensively review this condition and share the clinical recommendations made by our institution's multidisciplinary team.
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http://dx.doi.org/10.1155/2023/9279934 | DOI Listing |
J Surg Case Rep
January 2025
Department of Pathology, University Hospital of the West Indies, Kingston, Jamaica.
Gestational gigantomastia (GG) is a rare and severe clinical complication of pregnancy. It is characterized by dramatic and uncontrolled growth of the breasts, often leading to physical discomfort, psychological distress and significant surgical complications. Its pathophysiology is poorly understood; management options include conservative pharmacological and surgical interventions.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
December 2024
From the Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
True parenchymal breast changes following COVID-19 vaccination are exceedingly rare. Equally rare are incidences of pseudoangiomatous stromal hyperplasia (PASH)-associated gigantomastia. The patient in this case report presented with both occurrences and experienced massive breast enlargement 1 week postadministration of the Pfizer/BioNTech COVID-19 vaccine, which worsened after her second dose.
View Article and Find Full Text PDFCureus
November 2024
Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, USA.
Pseudoangiomatous stromal hyperplasia (PASH) is a benign but rare mesenchymal proliferation of the mammary stroma, characterized by pseudovascular spaces within a hyperplastic matrix. PASH can be classified as either non-tumor-forming or tumor-forming. The non-tumor-forming type is an infiltrative and clinically undetectable mass, incidentally found in approximately a quarter of breast biopsies.
View Article and Find Full Text PDFCureus
October 2024
General Surgery, Bharath Institute of Higher Education & Research, Chennai, IND.
Phyllodes tumor is a rare and particular type of breast tumor with features of stromal hyperplasia and malignant potential. The present case is an unusual presentation of a phyllodes tumor with pseudoangiomatous stromal hyperplasia (PASH) which forms an essential part of benign breast disease but is not frequently described in association with phyllodes tumor. A 36-year-old female patient was referred to the hospital with a large breast mass considered to be a benign growth.
View Article and Find Full Text PDFJ Int Med Res
November 2024
Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, China.
Pseudoangiomatous stromal hyperplasia (PASH) is a rare, benign breast lesion characterized by collagen proliferation, often identified as an incidental microscopic finding. Clinically, it may present as a palpable, well-defined breast mass or, in rare instances, as a diffuse, bilateral process leading to significant breast enlargement. We herein report a case of extensive diffuse PASH with short-term recurrence following lesion resection at another hospital.
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