AI Article Synopsis
- A 63-year-old woman with severe atopic dermatitis began treatment with dupilumab and developed respiratory symptoms like cough and fever shortly after.
- Lab tests revealed a high eosinophil count and imaging showed lung infiltrations, leading to a diagnosis of eosinophilic pneumonia.
- Treatment with prednisolone led to symptom resolution and improvement in lung imaging, marking this as a unique case following dupilumab treatment.
Article Abstract
A 63-year-old woman with refractory atopic dermatitis started treatment with dupilumab. She developed a cough 4 days later, sputum, and a slight fever 2 weeks later. Laboratory test results showed a blood eosinophil count of 7360/μL. Chest x-ray and computed tomography scan showed infiltrative shadows with surrounding consolidation of both upper lobes. Bronchoalveolar lavage fluid eosinophil count was increased (50.0%), and histopathological findings were consistent with numerous eosinophilic infiltrations. Treatment with prednisolone 30 mg/day (0.5 mg/kg/day) was initiated. Her symptom resolved, and the shadow of the lung fields improved. There have been no reported cases of eosinophilic pneumonia diagnosed 7 weeks after the administration of dupilumab for atopic dermatitis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352713 | PMC |
| http://dx.doi.org/10.1002/rcr2.1192 | DOI Listing |
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