In this article, two undescribed amides (1-2) with an unusual (2-formyl-5-hydroxymethyl)pyrroyl-butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HR-ESI-MS, coupling with spectroscopic data comparisons were used to determine structures. Anti-inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS-induced RAW 264.7 cells, with IC values of 17.52±1.68 μM and 20.37±2.42 μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202300556 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
: A Review of Ethnobotany, Phytochemistry, Pharmacology, Q-marker Prediction, and Future Directions.
Curr Top Med Chem
October 2024
College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Background: Upon the release of the selection results of "Qin Medicine," numerous Chinese herbal medicines and proprietary Chinese medicines have regained attention. (Huashanshen), a herbal medicine named after Mount Hua, the prominent peak in the Qinling Mountains, has garnered particular interest. Despite this, the impact of and medicines as a whole remains significantly overshadowed by the renown of Mount Hua.
View Article and Find Full Text PDFQualitative identification and quantitative comparison of Physochlainae Radix from different regions based on chemometric methods.
J Sep Sci
November 2023
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Physochlainae Radix (PR) is an essential herbal medicine that has been generally applied for treating cough and asthma. In this study, a comprehensive strategy for quality evaluation of PR from different origins was established by integrating qualitative identification, quantitative analysis, and chemometric methods. A total of 58 chemical components were identified by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS), and a sensitive and rapid UHPLC-QqQ-MS/MS method was established for the simultaneous determination of 12 compounds.
View Article and Find Full Text PDFTwo New Amides from Physochlainae Radix.
Chem Biodivers
September 2023
Shanxi Modern Chinese Medicine Engineering Laboratory, Shanxi University of Chinese Medicine, Jinzhong, 030619, P. R. China.
In this article, two undescribed amides (1-2) with an unusual (2-formyl-5-hydroxymethyl)pyrroyl-butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HR-ESI-MS, coupling with spectroscopic data comparisons were used to determine structures. Anti-inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS-induced RAW 264.
View Article and Find Full Text PDFUltrasonic Extraction of Tropane Alkaloids from Using as Extractant an Ionic Liquid with Similar Structure.
Molecules
August 2019
School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
In this research, tropane alkaloids in were extracted by tropine-type ionic liquid (IL) aqueous solutions under ultrasound assistance, and N-propyltropine hexafluorophosphate ([CTr][PF]) was found to be the most ideal IL in this extraction mode after comprehensive screening. When 0.03 mol/L [CTr][PF] aqueous solution was chosen as the extraction solvent, the solid-liquid ratio of raw material powders and ionic liquid aqueous solution was 1:20 (g/mL), ultrasonic power was 90 W and extraction time was 30 min, the extraction efficiency of tropane alkaloids has reached 121.
View Article and Find Full Text PDFExtraction and quantitative analysis of tropane alkaloids in Radix physochlainae by emulsion liquid membrane with tropine-based ionic liquid.
J Chromatogr A
January 2019
School of Chemical Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:
Emulsion liquid membrane (ELM) coupled with tropine-based ionic liquid was prepared and successfully adopted for the extraction and quantitative analysis of tropane alkaloids (TA) in Radix physochlainae. Effects of formation conditions of ELM were explored and then optimized; the ideal oil-water mass ratio was determined to be 1:2.5, chloroform, Span 80 and 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!