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Adipocyte-mediated electrophysiological remodeling of human stem cell - derived cardiomyocytes.
J Mol Cell Cardiol
April 2024
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Adipocytes normally accumulate in the epicardial and pericardial layers around the human heart, but their infiltration into the myocardium can be proarrhythmic. METHODS AND RESULTS: Human adipose derived stem/stromal cells and human induced pluripotent stem cells (hiPSC) were differentiated, respectively into predominantly white fat-like adipocytes (hAdip) and ventricular cardiomyocytes (CMs). Adipocytes cultured in CM maintenance medium (CM medium) maintained their morphology, continued to express adipogenic markers, and retained clusters of intracellular lipid droplets.
View Article and Find Full Text PDFProtective effect of human epicardial adipose-derived stem cells on myocardial injury driven by poly-lactic acid nanopillar array.
Biotechnol Appl Biochem
February 2024
Cheeloo College of Medicine, Shandong University& Shandong Qianfoshan Hospital, Jinan, China.
We investigated if poly-lactic acid (PLA) nanopillar array can trigger the differentiation of human epicardial (ADSCs) (heADSCs) into cardiomyocyte-like cells and explored the effects of these cardiomyocyte-like cells on myocardial infarction (MI) in vivo. PLA nanopillar array (200 nm diameter) and plain PLA film (PLA planar) induced heADSCs were marked with carboxyfluorescein. After 7 days, the expressions of myocardiocyte-specific genes were significantly enhanced in cells seeded on PLA nanopillar array compared with that on PLA planar, especially CACNA1C, KCNH2, and MYL2 genes (p < 0.
View Article and Find Full Text PDFEpicardial Adipose-Derived miR92a-3p: Stress Reduction Therapy?
J Am Coll Cardiol
July 2023
Department of Medicine, Cardiovascular Division, University of Massachusetts Chan School of Medicine, Worcester, Massachusetts, USA. Electronic address:
Mitochondrial Transfer Induced by Adipose-Derived Mesenchymal Stem Cell Transplantation Improves Cardiac Function in Rat Models of Ischemic Cardiomyopathy.
Cell Transplant
January 2023
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Article Synopsis
- Mesenchymal stem cell transplantation is effective in treating ischemic cardiomyopathy, but the exact mechanisms behind it are unclear, prompting research into mitochondrial transfer as a potential explanation.
- In experiments with human adipose-derived stem cells and rat heart cells under low-oxygen conditions, researchers found that mitochondrial transfer enhanced energy metabolism and required direct cell contact.
- After transplanting these stem cells into a rat model with heart damage, mitochondrial transfer was observed within 3 days, leading to the presence of donor mitochondrial DNA and notable improvements in heart function.
MiR-3064 in Epicardial Adipose-Derived Exosomes Targets Neuronatin to Regulate Adipogenic Differentiation of Epicardial Adipose Stem Cells.
Front Cardiovasc Med
August 2021
Department of Cardiovascular Surgery, Central People's Hospital of Zhanjiang, Zhanjiang, China.
The metabolism of epicardial adipose tissue (EAT) is closely related to coronary atherosclerotic heart disease (CAHD), but the specific mechanism is not fully understood. In this study, we investigated the effects of EAT microenvironment on adipose metabolism from the viewpoint of EAT-derived exosomes and epicardial adipose stem cells (EASCs). EAT samples from CAHD patients and non-CAHD patients were collected to obtain exosomes via tissue culture.
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