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http://dx.doi.org/10.1056/NEJMicm2215136DOI Listing

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Spread of Mycobacterium tuberculosis (MTB) to the larynx is exceedingly rare and can be obscured by more common conditions such as laryngeal cancer or oropharyngeal candidiasis, complicating an accurate diagnosis. Risk factors for chronic laryngeal disease, such as smoking and toxin exposure, place TB infection comparatively lower for consideration on a physician's differential. However, identifying these lesions is crucial from a medical and public health perspective to prevent community spread.

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Difficult glottis: Diagnostic dilemma in viewof the clinical presentation.

Otolaryngol Pol

July 2023

Department of Otolaryngology, Head and Neck Surgery, and Laryngological Oncology, Medical University of Karol Marcinkowski, Poznan, Poland.

<br><b>Introduction:</b> The taxonomy of vocal fold lesions has been refined, and it serves as a common descriptive language for diagnosis, treatment algorithms, and reporting of outcomes. However, we observe rare cases when numerous pathologies overlap, resulting in an unclear and complicated clinical presentation of the glottis.</br> <br><b>Aim:</b> The aim of this paper is to present cases of overlapping etiopathological factors which poses a challenge when making a diagnosis and referring a patient for adequate treatment.

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Article Synopsis
  • The text discusses the case of a 1-year-2-month-old boy with severe laryngitis and pneumonia caused by a coinfection of opportunistic pathogens in an immunodeficient patient, which is rare in children.
  • The child's immune deficiency is linked to a specific mutation in the STAT1 gene, known to be related to chronic fungal infections.
  • After targeted treatment with itraconazole and trimethoprim-sulfamethoxazole, the boy improved and remained symptom-free during a one-year follow-up.
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