AI Article Synopsis

  • The study examines the unique clinical features of Juvenile Psoriatic Arthritis (JPsA) in comparison to other types of Juvenile Idiopathic Arthritis (JIA) and how these features affect patient-reported outcomes and overall clinical results.
  • Researchers analyzed data from children and young adults diagnosed with JPsA and other JIA types over a period spanning nearly two decades, using various assessment tools to gauge health and wellbeing.
  • Findings revealed no significant differences in initial patient-reported outcomes between JPsA and non-JPsA cases, but JPsA patients with psoriasis experienced more depressive symptoms, indicating a need for integrated care that addresses both physical and psychological health in affected individuals.

Article Abstract

Objectives: Juvenile PsA (JPsA) has varied clinical features that are distinctive from other JIA categories. This study investigates whether such features impact patient-reported and clinical outcomes.

Methods: Children and young people (CYP) were selected if recruited to the Childhood Arthritis Prospective Study, a UK multicentre JIA inception cohort, between January 2001 and March 2018. At diagnosis, patient/parent-reported outcomes (as age-appropriate) included the parental global assessment (10 cm visual analogue scale), functional ability (Childhood Health Assessment Questionnaire (CHAQ)), pain (10 cm visual analogue scale), health-related quality of life (Child Health Questionnaire PF50 psychosocial score), mood/depressive symptoms (Moods and Feelings Questionnaire) and parent psychosocial health (General Health Questionnaire 30). Three-year outcome trajectories have previously been defined using active joint counts, physician and parent global assessments (PGA and PaGA, respectively). Patient-reported outcomes and outcome trajectories were compared in (i) CYP with JPsA vs other JIA categories and (ii) CYP within JPsA, with and without psoriasis via multivariable linear regression.

Results: There were no significant differences in patient-reported outcomes at diagnosis between CYP with JPsA and non-JPsA. Within JPsA, those with psoriasis had more depressive symptoms (coefficient = 9.8; 95% CI: 0.5, 19.0) than those without psoriasis at diagnosis. CYP with JPsA had 2.3 times the odds of persistent high PaGA than other ILAR categories, despite improving joint counts and PGA (95% CI: 1.2, 4.6).

Conclusion: CYP with psoriasis at JPsA diagnosis report worse mood, supporting a greater disease impact in those with both skin and joint involvement. Multidisciplinary care with added focus to support wellbeing in children with JPsA plus psoriasis may help improve these outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065439PMC
http://dx.doi.org/10.1093/rheumatology/kead370DOI Listing

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