AI Article Synopsis
- Sex-specific splicing is crucial for regulating sex determination and sexual dimorphism, but prior research hadn't examined the timing of this diversity at a genome-wide level.
- Our study demonstrates that widespread sex-specific transcript diversity occurs early in development, right alongside zygotic genome activation.
- We introduce a new tool, time2Splice, to track alternative splicing changes over time, and we found that losing the pioneer factor CLAMP disrupts sex-specific splicing of multiple developmental genes.
Article Abstract
Sex-specific splicing is an essential process that regulates sex determination and drives sexual dimorphism. Yet, how early in development widespread sex-specific transcript diversity occurs was unknown because it had yet to be studied at the genome-wide level. We use the powerful model to show that widespread sex-specific transcript diversity occurs early in development, concurrent with zygotic genome activation. We also present a new pipeline called time2Splice to quantify changes in alternative splicing over time. Furthermore, we determine that one of the consequences of losing an essential maternally deposited pioneer factor called CLAMP (chromatin-linked adapter for MSL proteins) is altered sex-specific splicing of genes involved in diverse biological processes that drive development. Overall, we show that sex-specific differences in transcript diversity exist even at the earliest stages of development..
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400075 | PMC |
| http://dx.doi.org/10.7554/eLife.87865 | DOI Listing |
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