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Tick populations and molecular detection of selected tick-borne pathogens in questing ticks from northern and central Tanzania. | LitMetric

Tick populations and molecular detection of selected tick-borne pathogens in questing ticks from northern and central Tanzania.

Exp Appl Acarol

Key Laboratory of Livestock Infectious Diseases in Northeast China, Key Laboratory of Zoonosis, Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China.

Published: August 2023

AI Article Synopsis

  • Ticks can carry various pathogens that cause tick-borne diseases (TBDs) in humans and livestock, impacting livestock production in tropical and subtropical areas, particularly in Tanzania, where research is limited.
  • A study identified 2021 ticks of nine species, revealing that 34.7% tested positive for pathogens, with Theileria parva being the most common, while Coxiella burnetii was not found at all.
  • The presence of tick-borne pathogens varied significantly by district, season, species, and developmental stage of ticks, highlighting the need for ongoing monitoring and control strategies for these diseases in the region.

Article Abstract

Ticks are vectors and reservoirs of a variety of pathogens including protozoa, bacteria and viruses which cause tick-borne diseases (TBDs) in humans and livestock. TBDs pose serious constraints to the improvement of livestock production in tropical and subtropical regions of the world. Despite their wide distribution, information on the tick and pathogen relationship is scarce in Tanzania. We used nested PCR and sequencing to screen pathogens of public and veterinary health importance in ticks collected by flagging from four districts of Tanzania. In total, 2021 ticks comprising nine species were identified. DNA from ticks was pooled according to tick species, developmental stage, and location, then screened for Babesia bigemina, Babesia bovis, Theileria parva and Coxiella burnetii. Out of 377 pools, 34.7% were positive for at least one pathogen. Theileria parva was the most abundant with a minimum infection rate (MIR) of 2.8%, followed by B. bigemina (MIR = 1.8%) and B. bovis (MIR = 0.8%). Multiple pathogens detection was observed in 7.2% of the tested pools. However, PCR screening of individual tick DNA revealed that only 0.3% of the examined pools had co-infection. DNA of C. burnetii was never detected in any tick DNA pool. The MIR of tick-borne pathogens (TBPs) differed significantly among districts, seasons, tick species, and tick developmental stages. Sequence analysis showed that B. bigemina RAP-1a, B. bovis SBP-4, and T. parva p104 genes were conserved among pathogens in the four districts. Despite the absence of C. burnetii in ticks, considering its pathogenic potential, it is essential to continue monitoring for its possible recurrence in ticks. This information adds to the knowledge of TBPs epidemiology and will contribute to the scientific basis for planning future control strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406711PMC
http://dx.doi.org/10.1007/s10493-023-00816-0DOI Listing

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