AI Article Synopsis
- - Four new diterpenoids (1-4) and sixteen known ones (5-20) were extracted from the plant Euphorbia helioscopia L., with compounds 1 and 2 categorized as rhamofolane, compound 3 as lathyranes, and compound 4 as jathophanes.
- - The isolated compounds were evaluated for their cytotoxicity and efficacy against the Zika virus, with compounds 9 and 15 demonstrating low cytotoxicity and high anti-Zika activity (EC values of 2.63 and 5.94 μM, respectively).
- - Researchers further assessed the inhibitory effects of these compounds on protein levels using techniques like Western blotting and immunof
Article Abstract
Four new diterpenoids (1-4) and sixteen known diterpenoids (5-20) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were rhamofolane diterpenoids with a 5/7/6 tricyclic systems, compound 3 was a lathyranes diterpenoid, and compound 4 was a jathophanes diterpenoid. The isolated compounds were tested for their cytotoxicity and anti-Zika virus properties, and compounds 9 and 15 showed low cytotoxicity and strong anti-Zika virus properties with EC 2.63 and 5.94 μM, respectively. Further, the inhibitory effects of compounds on protein levels were determined using Western blotting and immunofluorescence assays.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2023.105614 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!