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Article Synopsis
- JCO CheckMate 274 is a phase III trial comparing adjuvant nivolumab to placebo for high-risk muscle-invasive urothelial carcinoma (MIUC) post-surgery, showing improved disease-free survival (DFS) metrics with nivolumab treatment.
- The study documented results at a median follow-up of 36.1 months, with larger survival benefits noted for patients with positive PD-L1 expression.
- No new safety issues were discovered, reinforcing the role of nivolumab as standard treatment for high-risk MIUC following radical resection.
JCO Mesenchymal-epithelial transition (MET) signaling pathway plays a role in the pathogenesis of selected patients with papillary renal cell carcinoma (PRCC). In the phase II PAPMET trial (ClinicalTrials.gov identifier: NCT02761057), cabozantinib significantly prolonged progression-free survival and improved objective response rate compared with sunitinib in patients with advanced PRCC.
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