AI Article Synopsis
- A new method has been created for synthesizing both symmetric and asymmetric fused spiro[4.4]-nonane-dione derivatives.
- It involves a Diels-Alder reaction using spiro[4.4]nona-2,7-diene-1,6-dione as the dienophile, and the adduct undergoes immediate aromatization.
- Various systems, such as tetrabromoxylene/NaI, 1,3-diphenylisobenzofuran/BF, or substituted cyclones, can generate an active diene component for the reaction.
Article Abstract
A method for the synthesis of both symmetric and asymmetric fused spiro[4.4]-nonane-dione derivatives has been developed. It is based on a Diels-Alder reaction of spiro[4.4]nona-2,7-diene-1,6-dione as a dienophile component followed by immediate aromatization of the adduct. An active diene component can be generated using the tetrabromoxylene/NaI system, the 1,3-diphenylisobenzofuran/BF system, or substituted cyclones.
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| http://dx.doi.org/10.1021/acs.joc.3c00981 | DOI Listing |
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