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Unlabelled: The ECM is a complex and dynamic meshwork of proteins that forms the framework of all multicellular organisms. Protein interactions within the ECM are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and cell surface receptors are essential for the initiation of signal transduction and the orchestration of cellular behaviors. Here, we report the development of MatriCom, a web application ( https://matrinet.
View Article and Find Full Text PDFWhile pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, we here discover an onset of beta-cell death in juvenile zebrafish, which regulates beta-cell mass. Histologically, this beta-cell death is underestimated due to phagocytosis by resident macrophages.
View Article and Find Full Text PDFBarriers and challenges of establishing family physician policy for urban population; evidence from a qualitative study in Iran.
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School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
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View Article and Find Full Text PDFIdentification of human cranio-maxillofacial skeletal stem cells for mandibular development.
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Compared with long bone that arises from the mesoderm, the major portion of the maxillofacial bones and the front bone of the skull are derived from cranial neural crest cells and undergo intramembranous ossification. Human skeletal stem cells have been identified in embryonic and fetal long bones. Here, we describe a single-cell atlas of the human embryonic mandible and identify a population of cranio-maxillofacial skeletal stem cells (CMSSCs).
View Article and Find Full Text PDFA Distinguished Roadmap of Fibroblast Senescence in Predicting Immunotherapy Response and Prognosis Across Human Cancers.
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Article Synopsis
- Tumor resistance to immune checkpoint inhibitors may be connected to cellular senescence, particularly in fibroblasts, as shown by single-cell RNA sequencing analyses.
- A fibroblast senescence-associated transcriptomic signature (FSS) links cellular senescence to tumor progression and immune dysfunction, demonstrating high predictive accuracy for ICI responses using machine learning.
- CDC6 is identified as a key marker influencing ICI response by inducing fibroblast senescence and altering the tumor microenvironment, highlighting the potential for targeting fibroblast senescence in cancer therapy.
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