Unusual Selective Monitoring of -Dimethylformamide in a Two-Dimensional Material Field-Effect Transistor.

,-Dimethylformamide (DMF) is an essential solvent in industries and pharmaceutics. Its market size range was estimated to be 2 billion U.S. dollars in 2022. Monitoring DMF in solution environments in real time is significant because of its toxicity. However, DMF is not a redox-active molecule; therefore, selective monitoring of DMF in solutions, especially in polar aqueous solutions, in real time is extremely difficult. In this paper, we propose a selective DMF sensor using a molybdenum disulfide (MoS) field-effect transistor (FET). The sensor responds to DMF molecules but not to similar molecules of formamide, ,-diethylformamide, and ,-dimethylacetamide. The plausible atomic mechanism is the oxygen substitution sites on MoS, on which the DMF molecule shows an exceptional orientation. The thin structure of MoS-FET can be incorporated into a microfluidic chamber, which leads to DMF monitoring in real time by exchanging solutions subsequently. The designed device shows DMF monitoring in NaCl ionic solutions from 1 to 200 μL/mL. This work proposes the concept of selectively monitoring redox-inactive molecules based on the nonideal atomic affinity site on the surface of two-dimensional semiconductors.