AI Article Synopsis
- EZH2 is a key protein that suppresses gene expression by modifying histones, specifically impacting retinal development and the function of retinal progenitor cells.
- Abnormal levels of EZH2 have been linked to various ocular tumors and other eye-related diseases, including inherited retinal disorders and age-related conditions.
- This review discusses the role of EZH2 in these diseases and suggests that targeting EZH2 could be a promising therapeutic strategy for treating ocular conditions.
Article Abstract
EZH2, acting as a catalytic subunit of PRC2 to catalyze lysine 27 in histone H3, induces the suppression of gene expression. EZH2 can regulate cell proliferation and differentiation of retinal progenitors, which are required for physiological retinal development. Meanwhile, an abnormal level of EZH2 has been observed in ocular tumors and other pathological tissues. This review summarizes the current knowledge on EZH2 in retinal development and ocular diseases, including inherited retinal diseases, ocular tumors, corneal injury, cataract, glaucoma, diabetic retinopathy and age-related retinal degeneration. We highlight the potential of targeting EZH2 as a precision therapeutic target in ocular diseases.
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| http://dx.doi.org/10.2217/epi-2023-0147 | DOI Listing |
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