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| http://dx.doi.org/10.3389/fcell.2023.1242664 | DOI Listing |
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The temporal relationship between mitochondrial quality and renal tissue recovery following ischemia-reperfusion injury.
Heliyon
January 2025
School of Chemical and Biotechnology, SASTRA Deemed University, Tirumalaisamudram, Thanjavur, Tamil Nadu, India.
Background: Growing evidence indicates that disruptions in mitochondrial quality management contribute to the development of acute kidney injury (AKI), incomplete or maladaptive kidney repair, and chronic kidney disease. However, the temporal dynamics of mitochondrial quality control alterations in relation to renal injury and its recovery remain poorly understood and are addressed in this manuscript.
Method: ology: Male Wistar rats (n = 60) were subjected to varying durations of ischemia and reperfusion.
The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart.
Front Pharmacol
December 2024
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Cellular senescence is a condition characterized by stable, irreversible cell cycle arrest linked to the aging process. The accumulation of senescent cells in the cardiac muscle can contribute to various cardiovascular diseases (CVD). Telomere shortening, epigenetic modifications, DNA damage, mitochondrial dysfunction, and oxidative stress are known contributors to the onset of cellular senescence in the heart.
View Article and Find Full Text PDFReduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms.
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Shenzhen Key Laboratory of Marine Biomaterials, CAS-HK Joint Lab of Biomaterials, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055, PR China.
Magnesium (Mg) alloys are popular biodegradable metals studied for orthopedic and cardiovascular applications, mainly because Mg ions are essential trace elements known to promote angiogenesis and osteogenesis. However, Mg corrosion consists of oxidation and reduction reactions that produce by-products, such as hydrogen gas, reactive oxygen species, and hydroxides. It is still unclear how all these by-products and Mg ions concomitantly alter the microenvironment and cell behaviors spatially and temporally.
View Article and Find Full Text PDFSulforaphane, Urolithin A, and ZLN005 induce time-dependent alterations in antioxidant capacity, mitophagy, and mitochondrial biogenesis in muscle cells.
Sports Med Health Sci
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Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, ON, M3J 1P3, Canada.
Efficient signal transduction that mediates mitochondrial turnover is a strong determinant of metabolic health in skeletal muscle. Of these pathways, our focus was aimed towards the enhancement of antioxidant capacity, mitophagy, and mitochondrial biogenesis. While physical activity is an excellent inducer of mitochondrial turnover, its ability to ubiquitously activate and enhance mitochondrial turnover prevents definitive differentiation of the contribution made by each pathway.
View Article and Find Full Text PDFUncaria rhynchophylla alkaloid extract exerts neuroprotective activity against Parkinson's disease via activating mitophagy with the involvement of UCHL1.
J Ethnopharmacol
February 2025
State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, PR China. Electronic address:
Article Synopsis
- Uncaria rhynchophylla (UR) has neuroprotective properties and has shown promise in treating Parkinson's disease (PD) due to its active alkaloid components, although more research is needed on its therapeutic effects and mechanisms.
- The study investigates UR's alkaloid extract (URA) using methods like LC-MS and proteomics to evaluate its chemical composition and anti-PD activity in animal models, along with its effects on dopaminergic neurons.
- Results indicate that URA significantly improves motor functions in PD models and enhances dopamine levels and related proteins, suggesting it may work through pathways involving oxidative phosphorylation and mitochondrial function.
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