A highly selective remote C(sp)-H acetonation of -(quinolin-8-yl)amide scaffolds at the C5-position under microwave irradiation has been developed. In the absence of a transition-metal-catalyst, benzoyl peroxide (BPO)-promoted cross-dehydrogenation coupling (CDC) of -(quinolin-8-yl)amides with acetone/acetonitrile occurred smoothly to generate the corresponding 5-acetonated/acetonitriled -(quinolin-8-yl)amides in good yields. The transformation is operationally simple, rapid, easily scaled-up to the gram scale, and shows a broad substrate scope.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340454 | PMC |
| http://dx.doi.org/10.1039/d3ra03651k | DOI Listing |
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