AI Article Synopsis
- Protein C (PC) is a crucial vitamin K-dependent protein that helps control blood clotting and maintains blood flow in the body.
- A mutation in the PROC gene on chromosome 2q14.3 can lead to a deficiency in PC, resulting in various serious health issues like thrombosis or clotting disorders.
- The case of a 37-year-old woman is discussed, who experienced acute portal vein thrombosis as her first symptom of PC deficiency, presenting with severe abdominal pain, nausea, and blood in her vomit and stool.
Article Abstract
Protein C (PC) is an essential vitamin K-dependent protein that regulates thrombosis and hemostasis in the body. A mutation in the PROC gene on chromosome 2q14.3 results in PC deficiency. The clinical presentation of PC deficiency can vary, ranging from a single vein thrombosis to disseminated intravascular coagulation, purpura fulminans, or even life-threatening complications such as sepsis. Here, we present a case of a 37-year-old female who was found to have acute portal vein thrombosis as an initial presentation of PC deficiency. She presented to the hospital with acute onset of abdominal pain associated with nausea, blood-streaked emesis, and bloody bowel movement.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347885 | PMC |
| http://dx.doi.org/10.7759/cureus.40407 | DOI Listing |
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