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M-targeted anti-SARS-CoV-2 inhibitor-based drugs. | LitMetric

M-targeted anti-SARS-CoV-2 inhibitor-based drugs.

J Chem Res

School of Pharmaceutical and Chemical Engineering, ChengXian College, Southeast University, Nanjing, P.R. China.

Published: July 2023

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 is a global health emergency. The main protease is an important drug target in coronaviruses. It plays an important role in the processing of viral RNA-translated polyproteins and is highly conserved in the amino acid sequence and three-dimensional structure, making it a good drug target for which several small molecule inhibitors are available. This paper describes the various anti-severe acute respiratory syndrome coronavirus 2 inhibitor drugs targeting M discovered since the severe acute respiratory syndrome coronavirus 2 outbreak at the end of 2019, with all these compounds inhibiting severe acute respiratory syndrome coronavirus 2 M activity . This provides a reference for the development of severe acute respiratory syndrome coronavirus 2 M-targeted inhibitors and the design of therapeutic approaches to address newly emerged severe acute respiratory syndrome coronavirus 2 mutant strains with immune evasion capabilities.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333551PMC
http://dx.doi.org/10.1177/17475198231184799DOI Listing

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