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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962655 | PMC |
| http://dx.doi.org/10.1053/j.gastro.2023.06.035 | DOI Listing |
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Accounting for differential exclusions in the NordICC trial discloses stronger-than-reported effects of screening colonoscopy.
J Clin Epidemiol
January 2025
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Objective: Recently, results on colorectal cancer (CRC) incidence and mortality reduction by the offer of screening colonoscopy were reported for the first time from a randomized controlled trial (RCT), the Nordic-European Initiative on Colorectal Cancer (NordICC) trial. Despite randomization, there was a substantially lower proportion of post-randomization exclusions of CRC cases due to cancer registry-recorded date of diagnosis before recruitment in the invited group than in the usual-care group. We aimed to evaluate the impact of such differential exclusions on the trial's effect estimates on CRC risk.
View Article and Find Full Text PDFUnraveling the effects of screening colonoscopy on colorectal cancer early detection and prevention: the NordICC trial revisited.
Cancer Commun (Lond)
December 2024
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Survival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data.
BMC Gastroenterol
November 2024
Davidoff Cancer Center, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel.
Background: Colonoscopy as a common screening practice to prevent colorectal cancer lacks strong evidence. NordICC, the first randomized trial of colonoscopy screening, reported no clear clinical benefit for colonoscopy in the intention-to-screen population with suggested benefit in the risk of colorectal incidence and cancer-specific mortality in the per-protocol analyses. However, although the study was designed to perform survival analysis, no survival outcomes were reported since the underlying assumption for hazard ratio was not valid.
View Article and Find Full Text PDFDelayed Cancer Registration and Estimation of Screening Colonoscopy Effects.
JAMA Netw Open
October 2024
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Reporting Quality of Endoscopic Colorectal Cancer Screening Randomized Controlled Trials: Adherence to Recommendations and Interventions.
Gastro Hep Adv
June 2024
Division of Gastroenterology, Department of Medicine and Population Health, NYU Grossman School of Medicine, New York, New York.
Article Synopsis
- In 2013, the SPIRIT group introduced guidelines to enhance reporting quality in randomized controlled trials (RCTs), specifically targeting studies on endoscopic colorectal cancer screening.
- A review of five RCTs showed adherence to SPIRIT guidelines between 82.4% to 92.2%, with significant gaps in trial registration and informed consent reporting.
- Overall, 37% of participants invited to screening actually underwent the procedure, highlighting discrepancies in protocol adherence, particularly with one trial showing notably lower rates.
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