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Consumption of aspartame and risk of breast cancer in the Nurses' Health Studies.
J Natl Cancer Inst
October 2024
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Debate persists regarding the potential carcinogenicity of aspartame as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses' Health Study (NHS) and Nurses' Health study II (NHSII). We used Cox models to calculate HRs and 95% CIs.
View Article and Find Full Text PDFOne-pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology.
Luminescence
September 2024
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Aspartame is an artificial sweetener used in drinks and many foods. International Agency for Research on Cancer classified aspartame as possibly carcinogenic to humans (IARC Group 2B). In this study, a sensitive and selective spectrofluorimetric method was developed to detect aspartame.
View Article and Find Full Text PDFUnderstanding the link between aspartame and cancer.
Expert Rev Anticancer Ther
September 2024
Ramazzini Institute, Bologna, Italy.
Introduction: Aspartame, invented in 1965 by GD-Searle, is an intense artificial sweetener taste approximately 200 times as sweet as sucrose and used as an additive in more than 6,000 products. Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results.
View Article and Find Full Text PDFAspartame carcinogenic potential revealed through network toxicology and molecular docking insights.
Sci Rep
May 2024
Fenghua Hospital of Traditional Chinese Medicine, Ningbo, Zhejiang, China.
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and mechanisms of aspartame (L-α-aspartyl-L-phenylalanine methyl ester). Aspartame, a commonly used synthetic sweetener, is widely applied in foods and beverages globally. In recent years, its safety issues, particularly the potential carcinogenic risk, have garnered widespread attention.
View Article and Find Full Text PDFExploring Bitter and Sweet: The Application of Large Language Models in Molecular Taste Prediction.
J Chem Inf Model
May 2024
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Article Synopsis
- The study explores the importance of understanding bitter and sweet taste perceptions, especially with concerns over aspartame's safety.
- Researchers used advanced AI models like GPT-3.5 and GPT-4 to predict molecular taste characteristics and found that GPT-4 achieved 86% accuracy in this task.
- The research successfully created new molecular compounds with unique taste profiles, verifying their properties through various simulations and toxicity testing, showcasing the role of AI in health and chemical sciences.
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