A novel skeleton alkaloid was obtained from Portulaca oleracea L., which was identified as 10,11-dihydroxybenzo[5',6'] pentaleno[1',2':3,4]pyrrolo[2,1-b]oxazol-7(11bH)-one, named oleracone M, and its structure was determined using UHPLC-ESI-QTOF/MS, 1D NMR and 2D NMR spectroscopy, and circular dichroism. Then the bioactivities of the compound were investigated including the anti-inflammatory, anti-acetylcholinesterase and antioxidant activities. The results showed that the novel skeleton alkaloid exhibited the potent effect on inhibiting the secretion of IL-1β at 10 μM, anticholinesterase activity with IC value of 49.58 μM, and antioxidant activity with IC value of 66.43 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2023.105608 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hypermagnesemia- and Hyperphosphatemia-Associated Cardiac Arrest after Injection of a Novel Magnesium-Based Bone Cement in Spinal Surgery.
J Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopaedic Surgery, Singapore General Hospital, Singapore (Dr. Loh, Dr. Ling, Dr. Jiang, and Lim) and the Department of Surgical Intensive Care, Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore (Dr. Goh).
We report a case of pulseless electrical activity (PEA) associated with profound hypermagnesemia immediately after cementation of a novel magnesium-based cement in spine surgery. During T8 to T12 posterior instrumentation and decompression laminectomy for vertebral metastasis secondary to lung cancer, a 61-year-old Chinese woman developed sudden hypotension and went into PEA immediately after injection of a novel magnesium-based cement. Intraoperative fluoroscopic imaging did not show any notable cement extravasation.
View Article and Find Full Text PDFStructure, Nuclear Magnetic Resonance Data, Biological Activity, and Synthesis of the Okaramine Family Compounds.
J Agric Food Chem
January 2025
School of Pharmacy, Shenzhen Technology University, Shenzhen, Guangdong 518118, China.
The okaramine family of compounds, a class of alkaloids with broad-spectrum insecticidal activity, has been discovered from species of and . These okaramines, characterized by their complex structures and diverse biological activities, have attracted widespread attention from biologists and chemists. To date, only a few okaramines have been synthesized, notably the highly active okaramines A and B, which feature a polycyclic skeleton, including an azocine ring and an unprecedented 2-dimethyl-3-methyl-azetidine ring.
View Article and Find Full Text PDFNovel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect.
Nat Prod Bioprospect
January 2025
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People's Republic of China.
Teucrifarides A-D (1-4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen known analogs (5-20), were purified from Teucrium quadrifarium. The absolute forma of compounds 1-4 were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound 1 possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.
View Article and Find Full Text PDF[Prospects for the development of new drugs for the treatment of osteoporosis].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100730, China.
With the population aging, the prevalence of osteoporosis is rapidly increasing, which has become serious public health problem. At present, there is a severe shortage of effective anti-osteoporotic drugs in China, making it difficult to control the growing trend of osteoporosis. The key pathological mechanism of osteoporosis is bone homeostasis imbalance.
View Article and Find Full Text PDFShaping ability of NiTi reciprocating file systems R-motion and waveOne gold in mesial canals of mandibular molars; micro CT study.
Sci Rep
January 2025
Department of Endodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
The preservation of the original configurations of root canals during endodontic preparation is crucial for treatment success. Nickel-titanium (NiTi) rotary systems have been refined to optimize canal shaping while minimizing iatrogenic errors. This study aimed to evaluate and compare the shaping efficacy of the novel R-Motion (RM) and the established WaveOne Gold (WG) systems using micro-computed tomography (micro-CT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!