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Advances in the use of nanotechnology for treating gout.
Nanomedicine (Lond)
January 2025
Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, P. R. China.
Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels of uric acid. Its incidence rate rises with the increases of living standards and poor dietary habits, which has a considerable impact on the quality of life of the patients. Although there is a wide assortment of drugs available for the management of gout, the effectiveness and security of these drugs are limited by their poor chemical stability and insufficient targeting.
View Article and Find Full Text PDFA novel muscle network approach for objective assessment and profiling of bulbar involvement in ALS.
Front Neurosci
January 2025
Neurology Associate P.C., Lincoln, NE, United States.
Introduction: As a hallmark feature of amyotrophic lateral sclerosis (ALS), bulbar involvement significantly impacts psychosocial, emotional, and physical health. A validated objective marker is however lacking to characterize and phenotype bulbar involvement, positing a major barrier to early detection, progress monitoring, and tailored care. This study aimed to bridge this gap by constructing a multiplex functional mandibular muscle network to provide a novel objective measurement tool of bulbar involvement.
View Article and Find Full Text PDFSocial contact patterns and their impact on the transmission of respiratory pathogens in rural China.
Infect Dis Model
June 2025
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Introduction: Social contact patterns significantly influence the transmission dynamics of respiratory pathogens. Previous surveys have quantified human social contact patterns, yielding heterogeneous results across different locations. However, significant gaps remain in understanding social contact patterns in rural areas of China.
View Article and Find Full Text PDFAfternoon kick-off, evening kick-off, or night kick-off in the first German Bundesliga - A possible Injury risk factor?
SICOT J
November 2024
Department of Orthopedics and Trauma Surgery, Heinrich Heine University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Introduction: This retrospective cohort study aimed to evaluate the impact of kick-off time on the risk of injury for professional soccer players in the first German Bundesliga. It was hypothesized that late kick-off times would have a negative effect on muscle and ligament injuries to the ankle and knee.
Methods: Kick-off times and injury data were collected over 5 consecutive seasons (1530 matches; 2014-2019) from two media-based registries (transfermarkt.
Gut Microbiome in Impulsively Violent Female Convicts.
Neuropsychobiology
November 2024
Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Introduction: Impulsivity and aggression are often interlinked behavioral traits that have major implications for our society. Therefore, the study of this phenomenon and derivative interventions that could lead to better control of impulsive aggression are of interest.
Methods: We analyzed the composition and diversity of the gut bacterial microbiome of 33 impulsively violent female convicts with dissocial personality disorder and 20 non-impulsive age-matched women.
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