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Can't drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting. | LitMetric
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Can't drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting.

Nora Lakes Laura M Canaday Stephen N Waggoner

Med

Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

Published: July 2023

Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al. describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.

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 Source
http://dx.doi.org/10.1016/j.medj.2023.06.009DOI Listing

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