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Biomarkers.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Inexpensive, non-invasive tests may improve the identification of persons at increased risk for cognitive decline and dementia. We compared impairment in odor identification and global cognition with neuro-imaging biomarkers to predict cognitive decline and dementia in the population-based Mayo Clinic Study of Aging (MCSA).
Method: At the 2008 assessment, 647 participants who were ≥ 55 years old with at least one follow-up had the following procedures: modified Blessed Information-Memory-Concentration Test (BIMCT), 12-item Brief Smell Identification Test (BSIT), brain magnetic resonance imaging (MRI), and Positron Emission Tomography (PET) amyloid imaging with 11C-Pittsburgh compound B (11C-PiB).
Biomarkers.
Alzheimers Dement
December 2024
Edith Cowan University, Joondalup, Australia; Australian E-Health Research Centre, CSIRO, Perth, Western Australia, Australia.
Background: A growing body of research has confirmed the presence of epigenetic alterations in Alzheimer's disease (AD). While the causal relationship between these changes and AD remains uncertain, they offer a novel avenue to explore potential treatments. In this study, we aimed at characterising the methylation signatures of amyloid beta (Aβ) deposition, one of the main hallmarks of AD.
View Article and Find Full Text PDFBackground: Brain fluid flow plays a crucial role in maintaining brain health by eliminating potentially harmful waste products like amyloid-beta and tau [1-2]. This process is potentially facilitated by pulsations in the perivascular space, influenced by the neurovascular unit and autonomic nervous system, which may vary in brain diseases such as Alzheimer's disease (AD) [3-4]. Using a 7 Tesla MRI scanner and ultrafast echo-planar imaging (EPI), we developed a non-invasive neuroimaging methodology to characterize the in-vivo frequency and amplitude responses of pulsations of cerebrospinal fluid (CSF) flow.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Olfactory impairment appears early in the course of Alzheimer's Disease (AD) and may serve as a non-invasive early marker of AD. Few studies have examined the association between olfaction and blood biomarkers of AD neuropathology in large, diverse, community-based populations. Blood levels of amyloid-beta (Aβ and Aβ), phosphorylated-tau (p-tau) forms, glial fibrillary acidic protein (GFAP), and neurofilament-light chain (NfL) appear to reliably reflect corresponding brain neuropathologies and neurodegeneration.
View Article and Find Full Text PDFLcProt: Proteomics-based identification of plasma biomarkers for lung cancer multievent, a multicentre study.
Clin Transl Med
January 2025
Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
Background: Plasma protein has gained prominence in the non-invasive predicting of lung cancer. We utilised Zeolite Zotero NaY-based plasma proteomics to investigate its potential for multiple event predicting, including lung cancer diagnosis (task #1), lymph node metastasis detection (task #2) and tumour‒node‒metastasis (TNM) staging (task #3).
Methods: A total of 4703 plasma proteins were quantified from 241 participants based on a prospective cohort of 2757 participants.
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