A new general contact model is proposed for preventing inter-leaflet penetration of bio-prosthetic heart valves (BHV) at the end of the systole, which has the advantage of applying kinematic constraints directly and creating smooth free edges. At the end of each time step, the impenetrability constraints and momentum exchange between the impacting bodies are applied separately based on the coefficient of restitution. The contact method is implemented in a rotation-free, large deformation, and thin shell finite-element (FE) framework based on loop's subdivision surfaces. A nonlinear, anisotropic material model for a BHV is employed which uses Fung-elastic constitutive laws for in-plane and bending responses, respectively. The contact model is verified and validated against several benchmark problems. For a BHV-specific validation, the computed strains on different regions of a BHV under constant pressure are compared with experimentally measured data. Finally, dynamic simulations of BHV under physiological pressure waveform are performed for symmetrical and asymmetrical fiber orientations incorporating the new contact model and compared with the penalty contact method. The proposed contact model provides the coaptation area of a functioning BHV during the closing phase for both of the fiber orientations. Our results show that fiber orientation affects the dynamic of leaflets during the opening and closing phases. A swirling motion for the BHV with asymmetrical fiber orientation is observed, similar to experimental data. To include the fluid effects, fluid-structure interaction (FSI) simulation of the BHV is performed and compared to the dynamic results.
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http://dx.doi.org/10.1002/cnm.3754 | DOI Listing |
Eye (Lond)
January 2025
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Objectives: To use finite element (FE) modeling and in vivo optical coherence tomography (OCT) imaging to explore the effect of ciliary muscle traction on optic nerve head (ONH) deformation during accommodation.
Methods: We developed a FE model to mimic the ciliary muscle traction during accommodation, and varied the stiffness of the sclera, choroid, Bruch's membrane (BM), prelaminar neural tissue and lamina cribrosa (LC) to assess their effects on accommodation-induced ONH strains. To validate the FE model, OCT images of the right eyes' ONHs from 20 subjects (25 ± 1.
Sci Rep
January 2025
Institute for System Dynamics, University of Stuttgart, Waldburgstr. 19, 70563, Stuttgart, Germany.
Including sensor information in medical interventions aims to support surgeons to decide on subsequent action steps by characterizing tissue intraoperatively. With bladder cancer, an important issue is tumor recurrence because of failure to remove the entire tumor. Impedance measurements can help to classify bladder tissue and give the surgeons an indication on how much tissue to remove.
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January 2025
School of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan, China.
To investigate the effect of the filter device on the cleanliness of molten steel and the flow field distribution within the tundish. The tundish filters were designed into five groups of pores with 20°, 25°, 30°, 35° and 40° elevation angles, and the flow field distribution and impurity removal rate of molten steel were calculated by Discrete Phase Model (DPM). The results showed that the removal rate of impurity in the molten steel could be significantly improved by using the tundish filter with elevation angle.
View Article and Find Full Text PDFBMC Anesthesiol
January 2025
Department of Anesthesiology, Perioperative Medicine and Pain Management, 1611 NW 12, University of Miami, Miami, FL, 33136, USA.
Background: Prolonged tracheal extubation time is defined as an interval ≥ 15 min from the end of surgery to extubation. An earlier study showed that prolonged extubations had a mean 12.4 min longer time from the end of surgery to operating room (OR) exit.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Av. San Claudio y Av. 24 Sur, Col. San Manuel Ciudad Universitaria, Puebla C.P. 72570, Mexico. Electronic address:
This work presents the effect of Polyhydroxybutyrate nanospheres (PHB-NSs) on the bacterial activity of plasmonic nanoparticles (NPs). The PHB-NSs were used as a substrate for the metal-NPs. Silver and gold NPs in colloidal solution were synthesized by chemical reduction, while PHB-NSs were synthesized by a physical method.
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