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Awareness and use of tools to identify potentially inappropriate prescribing among physicians and pharmacists in Saudi Arabia: a nationwide cross-sectional study.
Int J Clin Pharm
December 2024
Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Background: Potentially inappropriate prescribing (PIP) contributes significantly to treatment burden, specifically in older people. Detecting PIP and improving prescribing practices are therefore crucial for ensuring patient safety and positive outcomes.
Aim: This study aimed to assess physicians' and pharmacists' awareness and use of tools to identify PIP, as well as their confidence in recommending medication for older people.
Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate.
Front Physiol
October 2024
Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States.
Cholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic neurons of the brain. Deletion of GIRK2 channels affects both GIRK2 homo- and heterotetrames and can lead to abnormal neuronal excitability, including conditions such as epilepsy and addiction.
View Article and Find Full Text PDFEditorial - "Special Collection: 30 Years of PIP" - Physicochemistry of Interfacial Phenomena.
Chemphyschem
July 2024
Department of Applied Chemistry, Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614, Poznań, Poland.
2023 marked the 30 anniversary of the Section of Physicochemistry of Interfacial Phenomena (PIP) of the Polish Chemical Society (PCS). It was established in 1993 on the initiative of members of the Lublin Branch of PCS. On May 18 the same year, the Chairman of the Branch, Prof.
View Article and Find Full Text PDFEditorial: Women in science - regulatory science 2023.
Front Med (Lausanne)
March 2024
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases.
Front Immunol
March 2024
Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Introduction: In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells.
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