The stress-strain relationship for human skin in vivo has a characteristic non linear shape even for low loads. Considerations are given on the basis of which a structural model has been selected, in which the mechanical properties of corrugated collagen fibrils are involved. It is found that such a model can describe the experimental stress-strain relationship surprisingly well with only three free parameters. These parameters are related to basic collagen fibril properties such as stiffness, diameter and waviness. The role of elastin is likely to be negligible for the purely elastic properties of human skin in vivo.
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http://dx.doi.org/10.1016/0021-9290(86)90125-9 | DOI Listing |
Trials
January 2025
Université Côte d'Azur, CNRS, LP2M, Nice, France.
Background: /aims. Pseudoxanthoma Elasticum (PXE, OMIM 264800) is an autosomal, recessive, metabolic disorder characterized by progressive ectopic calcification in the skin, the vasculature and Bruch's membrane. Variants in the ABCC6 gene are associated with low plasma pyrophosphate (PPi) concentration.
View Article and Find Full Text PDFBMC Palliat Care
January 2025
Palliative Care Unit, National Cancer Institute, Rio de Janeiro, Brazil.
Objective: To compare the sociodemographic and clinical profiles of patients with advanced cancer admitted to a tertiary palliative care unit before and during the COVID-19 pandemic.
Methods: This is an analysis of data from patients receiving care before (10/21/2019 to 03/16/2020) and during (09/23/2020 to 08/26/2021) the COVID-19 pandemic. Sociodemographic and clinical data were evaluated.
Sci Rep
January 2025
The Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Difficult-to-heal wounds management accounts for about 4% of healthcare costs, highlighting the need for innovative solutions. Extracellular signals drive cell proliferation during tissue regeneration, while epigenetic mechanisms regulate stem cell homeostasis, differentiation, and skin repair. Exploring epigenetic regulation in adipose-derived stem cells (ADSCs) holds promise for improving skin injury treatments.
View Article and Find Full Text PDFSci Rep
January 2025
Institute of Geography, School of GeoSciences, University of Edinburgh, Edinburgh, UK.
Research has proved a close relationship between environments and physiological as well as psychological responses. However, existing research based on neuroscience experiments demonstrated a clear dichotomy between natural and built environments in the selection of exposure settings. There is very limited research analyzing and comparing the effects of different urban environments on individual psychological health.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Textile and Clothing Engineering, Soochow University, 199 Ren-ai Road, Suzhou 215123, China; Jiangsu Engineering Research Center of Textile Dyeing and Printing for Energy Conservation, Discharge Reduction and Cleaner Production (ERC), 215123, China; State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China. Electronic address:
Conductive organohydrogel fibers based on sodium alginate (SA) exhibit remarkable flexibility and electrical conductivity, making them ideal candidates for conformal skin adhesion and real-time monitoring of human activity signals. However, traditional conductive hydrogels often suffer from issues such as uneven distribution of conductive fillers, and achieving the integration of high mechanical strength, stretchability, and transparency using environmentally friendly methods remains a significant challenge. In this study, a novel and sustainable strategy was developed to fabricate dual-network organohydrogel fibers using sodium alginate as the primary material.
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