AI Article Synopsis
- - Early embryo development is crucial for determining an organism's health and traits, and stem cell lines have been used for years to study this process.
- - Advances in stem cell culture have led to the creation of complex 3D structures that resemble early embryos, called blastoids, representing a major breakthrough in research.
- - This mini-review explores recent advancements in stem cell-based embryo models, their future potential, and their impact on understanding early mammalian development.
Article Abstract
Early embryo development is a highly dynamic process that plays a crucial role in determining the health and characteristics of an organism. For many years, embryonic and extraembryonic stem cell lines representing various developmental stages have served as valuable models for studying early embryogenesis. As our understanding of stem cell culture and embryo development has advanced, researchers have been able to create more sophisticated 3D structures mimicking early embryos, such as blastocyst-like structures (blastoids). These innovative models represent a significant leap forward in the field. In this mini-review, we will discuss the latest progress in stem cell-based embryo models, explore potential future directions, and examine how these models contribute to a deeper understanding of early mammalian development.
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| http://dx.doi.org/10.1016/j.gde.2023.102088 | DOI Listing |
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