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Retinal microvascular dysfunction in systemic sclerosis.
Microvasc Res
December 2024
Department of Cardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland; Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:
Background And Aims: Systemic sclerosis (SSc) is a systemic autoimmune disease, characterized by widespread microvasculopathy and fibrosis. Vascular and endothelial cell changes appear to precede other features of SSc. Retinal vascular analysis is a new, easy-to-use tool for the assessment of retinal microvascular function.
View Article and Find Full Text PDFInterplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity.
Proc Natl Acad Sci U S A
December 2024
Paris Cardiovascular Research Center, Université Paris Cité, Inserm U970, Paris F-75015, France.
The integrity of the blood-retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB leads to the development of retinal diseases. Here, we show that Netrin-1/Unc5b and Norrin/Lrp5 signaling establish a zonated endothelial cell gene expression program that controls BRB integrity.
View Article and Find Full Text PDFEvaluation of the effect of hemodynamic factors on retinal microcirculation by using 3D confocal image-based computational fluid dynamics.
Front Bioeng Biotechnol
November 2024
Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Purpose: To investigate local hemodynamic changes resulting from elevated intraocular pressure (IOP) in different vasculature networks using a computational fluid dynamics model based on 3D reconstructed confocal microscopic images.
Methods: Three-dimensional rat retinal vasculature was reconstructed from confocal microscopy images using a 3D U-Net-based labeling technique, followed by manual correction. We conducted a computational fluid dynamics (CFD) analysis on different retinal vasculature networks derived from a single rat.
Associations of Cumulative Adulthood, Childhood and Life-long Insulin with Adulthood Retinal Microvasculature.
J Clin Endocrinol Metab
December 2024
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Context: Exogenous insulin is reported to have both vasodilatory and vasoconstrictive effects on the microvasculature. Little is known about the associations of long-term endogenous insulin exposure with microvasculature.
Objective: To test the hypothesis that long-term exposure to high insulin levels in childhood and adulthood is associated with adverse changes in retinal microvasculature in adulthood in a population without diabetes.
A Model to Predict the Risk of Adverse Ocular Outcomes in Pregnant Women.
Br J Hosp Med (Lond)
November 2024
Ophthalmology Department, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Article Synopsis
- Pregnancy can impact bodily functions, including eyesight, and conditions like preeclampsia and gestational diabetes are linked to eye changes during this time.
- A study analyzed medical records of 760 pregnant women to identify maternal health factors affecting ocular risks using logistic regression and ROC curve analysis.
- Key predictors for adverse ocular outcomes included eclampsia, gestational diabetes, chronic hypertension, and specific maternal characteristics, with ROC curves indicating moderate predictive accuracy.
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